56157-48-3Relevant academic research and scientific papers
2-Metallated Oxazoles; pKa Dependent Deuterations, NMR Studies and Palladium Catalysed Couplings
Crowe, Eleanor,Hossner, Frank,Hughes, Mark J.
, p. 8889 - 8900 (1995)
Deuteration experiments on 2-lithiated oxazoles show a pKa dependent regioselectivity suggesting that the ring cleaved tautomer dominates the equilibrium.Transmetallation to the zinc derivative gives a species which behaves as a C2 ring closed nucleophile as judged by deuteration and palladium catalysed coupling experiments.These conclusions are supported by nmr spectroscopy studies of the metallated species.
Copper-mediated formally dehydrative biaryl coupling of azine N -oxides and oxazoles
Odani, Riko,Hirano, Koji,Satoh, Tetsuya,Miura, Masahiro
, p. 2384 - 2391 (2015)
A copper-mediated formally dehydrative biaryl coupling of azine N-oxides and oxazoles has been developed. The C-C bond-forming process proceeds, accompanied by the removal of the oxygen atom from the azine core, to directly afford the azine-oxazole biaryl linkage. Moreover, this system requires no noble transition metals such as palladium and rhodium, which are common promotors in the related dehydrogenative couplings with the azine N-oxide. Thus, the present protocol can provide a unique and less expensive approach to the azine-containing biheteroaryls of substantial interest in pharmaceutical and medicinal chemistry.
