56159-57-0Relevant academic research and scientific papers
An efficient one-pot synthesis of coumarin-amino acid derivatives as potential anti-inflammatory and antioxidant agents
Bodke, Yadav D.,Naik, Mamata Devendra,Revanasiddappa, B. C.,Vijay Kumar, M.
, (2020/03/19)
A series of seven coumarinyl-amino acid ester conjugates have been synthesized and characterized by NMR (1H and 13C) and mass spectra. Further, the compounds were investigated for their therapeutic applications such as anti-inflammatory and antioxidant activities. Among the synthesized compounds most of the analogs showed good efficiency compared with the standard.
Synthesis of novel coumarin derivatives and in vitro biological evaluation as potential ptp 1b inhibitors
Sun, Cheng,Peng, Chune,Wang, Jian,Wang, Quan,Liu, Wei,Zhou, Honggang,Yang, Cheng
, p. 1711 - 1726 (2013/09/12)
The aim of protein tyrosine phosphatase 1B (PTP 1B) inhibitors is to develop effective drug for diabetes and obesity. Coumarin becomes as a good skeleton, and is often applied in drug design and synthesis. In this paper, we have synthesized a series of novel coumarin derivatives to be as potential PTP 1B inhibitors. The inhibition rate of compound 9 was more than 80%, and the IC50 value was 49.2 μM, which would be considered for further study.
