5620-35-9

Upstream product

• 100-26-5 Pyridine-2,5-dicarboxylic acid 

Downstream Products

• 102594-76-3 pyridine-2,5-dicarboxylic acid bis-phenacylamide 
• 4663-96-1 pyridine-2,5-dicarboxylic acid diamide 
• 5552-44-3 ethyl 2,5-pyridinedicarboxylate 
• 1078168-78-1 C₂₁H₁₅N₃O₆ 
• 313557-37-8 N,N′-diphenylpyridine-2,5-dicarboxamide 
• 6011-55-8 2,5-pyridinedicarboxylic dihydrazide 
• 1172634-77-3 C₂₃H₂₁NO₂ 
• 1172634-76-2 C₂₃H₂₁NO₂ 
• 24202-70-8 pyridine-2,5-dicarboxylic acid dibenzyl ester 
• 40875-87-4 2,5-bis-(5-phenyl-oxazol-2-yl)-pyridine 
• 42239-18-9 2,5-bis(bromomethyl)pyridine 
• 37877-95-5 [2](1,4)benzeno[2](2,5)pyridinophane 
• 21514-99-8 2,5-bis[hydroxymethyl]-pyridine 

Relevant academic research and scientific papers

Synthesis and characterization of new polyesters based on 2,5-bis[(4-chloro carboxyanilino) carbonyl] pyridine and aromatic diols

Six new polyesters 7a-f were synthesized through the solution polycondensation reaction of diacid chloride 5 with six aromatic diols 6a-f in N,N-dimethyl acetamide (DMAc) as solvent in the presence of pyridine as base. The polycondensation reaction produced a series of novel polyester containing pyridyl moiety in the main chain in high yields with inherent viscosities between 0.35 and 0.54 dL/g. The resulted polymers were fully characterized by means of FT-IR spectroscopy, elemental analyses, inherent viscosity and solubility tests. Thermal properties of these polymers were investigated by using thermal gravimetric analysis (TGA) and differentional thermal gravimetric (DTG). The glass-transition temperatures of these polyesters were recorded between 130 and 170 °C by differential scanning calorimetry (DSC) and the 10% weight loss temperatures were ranging from 390 to 450 °C under nitrogen.

Synthesis and properties of chiral amide-bonded porphyrin dimers with various functional bridging blocks

Eight porphyrin dimers with various functional bridging blocks and chiral amide-bonds were synthesized and characterized. An analysis of the spectroscopy and electrochemistry has been carried out to demonstrate that the chiral properties can be modified b

A COMPOUND, A REACTION PRODUCT OF SAID COMPOUND AND PRODUCTION METHODS THEREOF

There is provided a compound represented by general formula (lb), wherein ring A is a carbocyclic or heterocyclic ring, a reaction product of the reaction between one or more said compounds and one or more amine containing compounds. Also provided is related production methods thereof.

DIMERIC COMPOUNDS

Disclosed are compounds of Formula (I), or pharmaceutically acceptable salts thereof, wherein Z, X, Q and R1 are as described in this application, and methods of using the compounds in the treatment of cancer.

Probing the intermolecular interactions of aromatic amides containing N-heterocycles and triptycene

A series of aromatic amides incorporated with N-heterocycles or triptycene units are synthesized and studied for probing the effects of such chemical modifications on the intermolecular interactions. Single crystals of a number of heterocyclic amides and the triptycene-containing amide were obtained. Crystal structures, hydrogen bonds, lattice energy, solubility, and melting points were compared amongst relevant molecules. Suitably positioned nitrogen atoms from heterocycles are found to form intramolecular H-bonds with amide NHs at the expense of weakening or disrupting the intermolecular H-bonds. The effects of such H-bonding changes on solubility and melting point are nonetheless limited. Uniquely, the triptycene unit effectively improves the solubility of the amide without tempering the thermal resistance of the molecule. This journal is the Partner Organisations 2014.

Primary coloured electrochromism of aromatic oxygen and sulfur diesters

Eleven aromatic diesters and thioic S,S′-diesters were synthesized and investigated using electrochemical (cyclic voltammetry and controlled potential electrolysis) and UV-vis spectroscopic techniques over a range of temperatures. Nine of the compounds exhibited vibrant colour changes from a colourless state in their neutral forms to brightly coloured upon one-electron electrochemical reduction in acetonitrile. The compounds were found to display either red, green or blue colours in their one-electron reduced states. The electrochromic properties of 3 of the compounds that displayed the most vibrant colour changes were examined in solution using a gold micro-mesh electrode laminated inside a polymer film.

Synthesis and Biological Evaluation of Oral Prodrugs Based on the Structure of Gemcitabine

A series of oral prodrugs based on the structure of gemcitabine (2′,2′-difluorodeoxycytidine) were synthesised by introducing an amide group at the N4-position of the cytidine ring. A total of 16 compounds were obtained, and their chemical and biological characteristics were evaluated. The half-maximal inhibitory concentrations (IC50s) for most of these compounds were higher than that of gemcitabine in vitro. Compounds 5d and 5m, the representative compounds, were examined in terms of their physiological stabilities and pharmacokinetics. Compound 5d showed good stability in PBS and simulated intestinal fluid, and an analysis of its pharmacokinetics in mice suggested that the introduction of an amide group to gemcitabine could greatly improve its bioavailability. Further evaluation of compound 5din vivo showed that this compound possesses higher activity than gemcitabine against the growth of HepG2 human hepatocellular carcinoma cells and HCT-116 colon adenocarcinoma cells with less toxicity to animals. These results suggest that compound 5d could be further developed as a potential oral anticancer agent for clinical applications in which gemcitabine is currently used. A series of oral prodrugs based on the structure of gemcitabine were synthesized. Physiological and metabolic stabilities, pharmacokinetics and antitumor activities were evaluated for representative compounds.

Heterocyclic Compound

A compound represented by the following Formula (1): wherein, Het1 represents a bivalent five- or six-membered aromatic heterocyclic residue and may further be substituted; Xa to Xd each independently represent a heteroatom and may further be substituted; Ya to Yf each independently represent a heteroatom or a carbon atom and may further be substituted; the ring bound to Het1 may have a double bond at any position

Cyclization of propargylic amides: Mild access to oxazole derivatives

The substrate scope, the mechanistic aspects of the gold-catalyzed oxazole synthesis, and substrates with different aliphatic, aromatic, and functional groups in the side chain were investigated. Even molecules with several propargyl amide groups could easily be converted, delivering di- and trioxazoles with interesting optical properties. Furthermore, the scope of the gold(I)-catalyzed alkylidene synthesis was investigated. Further functionalizations of these isolable intermediates of the oxazole synthesis were developed and chelate ligands can be obtained. The use of Barluenga's reagent offers a new and mild access to the synthetically valuable iodoalkylideneoxazoles from propargylic amides, this reagent being superior to other sources of halogens.

1,5-DIHETEROCYCLE-1H-TRIAZOLE DERIVATIVE

The present invention relates to a compound represented by Formula (I): wherein Ar1, Ar2, R1 and R2 each represent a substituent, a salt thereof, or a solvate of the compound or the salt, and to a medicine containing the same. According to the present invention, a potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.