562069-23-2

Upstream product

• 108-88-3 toluene 
• 104115-64-2 2-bromo-7-methyl-1,2,3,4-tetrahydronapthalin-1-one 
• 22009-37-6 7-methyl-3,4-dihydro-2H-naphthalen-1-one 
• 562069-25-4 7-methyl-1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl-2-(4-methylsulfanylphenyl)acetate 

Relevant academic research and scientific papers

Synthesis and cyclooxygenase (COX-1/COX-2) inhibiting property of 3,4-diarylfuranones

A series of diarylfuranone including some 5-hydroxy derivatives and naphthofuranones have been synthesized as a unique class of COX-1/COX-2 inhibitors. In contrast to the earlier report of structurally similar rofecoxib, these compounds have been characterized as nonselective but highly potent COX inhibitors. Structure Activity Relationship study confirmed that methoxy and methylsulfanyl moieties are essential for COX activity and replacement or removal of any of this group affect COX-2 potency drastically rather than COX-1 efficacy. Studies on in vitro, in vivo screens and pharmacokinetics are discussed.

Conformationally restricted 3,4-diarylfuranones (2,3a,4,5-tetrahydronaphthofuranones) as selective cyclooxygenase-2 inhibitors

A number of naphthofuranones were synthesized and tested for COX-1 and COX-2 inhibition. Few of them were identified as selective COX-2 inhibitors. Structure-activity relationship studies within the series are discussed.