562069-99-2Relevant academic research and scientific papers
Synthesis of biologically important new 1, 4-benzothiazines bearing thiazole substituted aroyl moiety
Ingle,Bhingolikar,Bondge,Mane
, p. 695 - 698 (2007/10/03)
2-Acyl-4-(2′-methyl/phenyl/nicotinyl-thiazol-4′-yl) phenols 1 have been obtained from the condensation of 2, 4-diacylphenol and thioamides in one pot using phenyl trimethyl ammonium tribromide(PTT). The compounds 1 are then converted to their respective esters 2 by condensing with aroyl chlorides. The esters 2 are then subjected to B.V. transformation to yield 1-phenyl-3-[2′-hydroxy-5′-(2″-substitutedthiazol-4 ′-yl)]phenylpropane-1, 3-diones 3. These diones 3 and 2-aminobenzenethiol when allowed to react in DMSO afford the cyclocondensed products 2-[2′-hydroxy-5′-(2″-substitutedthiazol-4″-yl) benzoyl]-3-(4′-substitutedphenyl)-1, 4-benzothiazines 4. The structures of the new products 4 have been confirmed by elemental and spectral methods. The results of the microbial screening of the compounds are also recorded.
