562075-34-7Relevant academic research and scientific papers
Synthesis, molecular structure, and applications of 2-hydroxylamino-4,5-dihydroimidazolium-o-sulfonate to the synthesis of novel heterocyclic ring systems
Saczewski, Franciszek,Saczewski, Jaroslaw,Gdaniec, Maria
, p. 4791 - 4796 (2003)
2-Hydroxylamino-4,5-dihydroimidazolium-O-sulfonate (1) has been prepared by reacting 2-chloro-4,5-dihydroimidazole with hydroxylamine-O-sulfonic acid. Deprotonated compound la containing both the nucleophilic endocyclic nitrogen atoms and electrophilic exocyclic nitrogen was used for the syntheses of 3-substituted 6,7-dihydro-5H-imidazo[2,1-c] [1,2,4]oxadiazoles 2-9 and 6,7-dihydro-5H-imidazo[2,1-c][1,2,4]thiadiazole-3-thione (10) by tandem nucleophilic addition-electrophilic amination reaction. The method promises utility in the synthesis of a variety of other heterocycles. On the other hand, the convenient routes to 7,8-dihydroimidazo [1,2-c][1,3,5]thiadiazine-2,4(6H)-dithione (16) and 2,6,7,8-tetrahydroimidazo[1,2-][1,3,5]triazine-4(3H)-thione derivative (17) are reported starting from compound 1. The structures of the compounds prepared were established by elemental analyses, IR, NMR, and MS spectra, and in some instances X-ray analyses.
Synthesis, X-ray structure analysis and computational studies of novel bis(thiocarbamoyl) disulfides with non-covalent S?N and S?S interactions
Saczewski, Jaros?aw,Frontera, Antonio,Gdaniec, Maria,Brzozowski, Zdzis?aw,Saczewski, Franciszek,Tabin, Piotr,Qui?onero, David,Deyà, Pere M.
, p. 234 - 239 (2006)
In this Letter, we describe the synthesis of several bis(thiocarbamoyl) disulfides that present interesting intramolecular S?N and S?S interactions. In one case, crystals suitable for X-ray characterization have been obtained. The non-covalent interaction
