56208-17-4Relevant academic research and scientific papers
Manganese-Catalyzed Selective Hydrogenative Cross-Coupling of Nitriles and Amines to Form Secondary Imines
Li, Xiao-Gen,Zhou, Qi-Lin
supporting information, p. 3471 - 3475 (2021/04/29)
Manganese complexes with tridentate PNN ligands have been synthesized as catalysts for hydrogenative cross-coupling reaction of nitriles and amines to form secondary imines. This reaction afforded a variety of unsymmetrical secondary imines in good yields with excellent selectivity. Investigation of catalyst intermediates indicated that an amido manganese complex may be the active catalyst species for this reaction. (Figure presented.).
Synthesis of polyheterocyclic pyrrolo[3,4-b]pyridin-5-ones via a one-pot (Ugi-3CR/aza diels-alder/N-acylation/aromatization/SN2) process. A suitable alternative towards novel Aza-analogues of falipamil
Zamudio-Medina, Angel,García-González, Ailyn N.,Herrera-Carrillo, Genesis K.,Zárate-Zárate, Daniel,Benavides-Macías, Adriana,Tamariz, Joaquín,Ibarra, Ilich A.,Islas-Jácome, Alejandro,González-Zamora, Eduardo
, (2018/04/06)
We describe the one-pot synthesis of twenty polyheterocyclic pyrrolo[3,4-b]pyridin-5-ones via a cascade process (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization) in 20 to 95% overall yields, as well as four pharmacologically promising analogues via an improved cascade process (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization/SN2): two piperazine-linked pyrrolo[3,4b]pyridin-5-ones in 33 and 34%, and a couple of Falipamil aza-analogues in 30 and 35% overall yields. It is worth highlighting the good substrate scope found, because final products are furnished with alkyl, aryl, and heterocyclic substituents. The use of chain-ring tautomerizable isocyanides (as key reagents for the Ugi-type three component reaction) allowed for a rapid and efficient assembly of the polysubstituted oxindoles, which were used in situ toward the complex products, conferring features like robustness, sustainability, and the one-pot approach to this synthetic methodology.
3,3-Dichloro-2-azetidinone derivatives
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, (2008/06/13)
Compounds having the formula STR1 wherein A1 is an alkylene group having 2 to 4 carbon atoms; R1 is dialkylamino or a nitrogen containing heterocyclic group and R2 is phenyl, substituted phenyl, naphthyl, or 1,3-benzodioxo
