562106-02-9Relevant academic research and scientific papers
1,6 naphthyridines useful as inhibitors of SYK kinase
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, (2008/06/13)
Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell ac
Discovery and SAR of novel [1,6]naphthyridines as potent inhibitors of Spleen Tyrosine Kinase (SYK)
Cywin, Charles L.,Zhao, Bao-Ping,McNeil, Daniel W.,Hrapchak, Matt,Prokopowicz III, Anthony S.,Goldberg, Daniel R.,Morwick, Tina M.,Gao, Amy,Jakes, Scott,Kashem, Mohammed,Magolda, Ronald L.,Soll, Richard M.,Player, Mark R.,Bobko, Mark A.,Rinker, James,DesJarlais, Renee L.,Winters, Michael P.
, p. 1415 - 1418 (2007/10/03)
The discovery of novel 5,7-disubstituted[1,6]naphthyridines as potent inhibitors of Spleen Tyrosine Kinase (SYK) is discussed. The SAR reveals the necessity for a 7-aryl group with preference towards para substitution and that this in combination with 5-aminoalkylamino substituents further improved the potency of the compounds. The initial SAR as well as a survey of the other positions is discussed in detail.
