261635-93-2

Basic information

• Product Name: 2-METHYL-6-(TRIFLUOROMETHYL)NICOTINIC ACID
• Synonyms: BUTTPARK 27\06-89;2-METHYL-6-(TRIFLUOROMETHYL)NICOTINIC ACID;2-METHYL-6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXYLIC ACID;2-Methyl-6-(trifluoromethyl)nicotinic acid, Tech.;2-Methyl-6-(trifluoromethyl)pyridine-3-carboxylic acid, 3-Carboxy-2-methyl-6-(trifluoromethyl)pyridine
• CAS NO: 261635-93-2
• Molecular Formula: C₈H₆F₃NO₂
• Molecular Weight: 205.13
• Product Categories: Carboxylic Acids;Pyridines;Carboxylic Acids
• Mol File: 261635-93-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 139-141℃
• Boiling Point: 253.0±40.0℃ (760 Torr)
• Flash Point: 106.8±27.3℃
• Appearance: /
• Density: 1.414±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.01mmHg at 25°C
• Refractive Index: 1.479
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 2.51±0.25(Predicted)
• Water Solubility: Slightly soluble in water (4.7 g/L at 25°C).
• CAS DataBase Reference: 2-METHYL-6-(TRIFLUOROMETHYL)NICOTINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-6-(TRIFLUOROMETHYL)NICOTINIC ACID(261635-93-2)
• EPA Substance Registry System: 2-METHYL-6-(TRIFLUOROMETHYL)NICOTINIC ACID(261635-93-2)

Safety Data

• Hazard Codes: C,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 261635-93-2(Hazardous Substances Data)

Usage

Uses

2-Methyl-6-(trifluoromethyl)nicotinic acid is used as a pharmaceutical intermediate.

InChI:InChI=1/C8H6F3NO2/c1-4-5(7(13)14)2-3-6(12-4)8(9,10)11/h2-3H,1H3,(H,13,14)

Upstream product

• 205582-88-3 methyl 2-methyl-6-(trifluoromethyl)nicotinate 
• 402479-93-0 2-methyl-6-(trifluoromethyl)nicotinonitrile 

Downstream Products

• 20034-50-8 4-cyclopropylbenzaldehyde 
• 545394-83-0 2-methyl-6-(trifluoromethyl)pyridine-3-carboxaldehyde 
• 676533-86-1 N-(tert-butyl)-2-methyl-6-(trifluoromethyl)nicotinamide 
• 681260-50-4 (2-methyl-6-(trifluoromethyl)pyridin-3-yl)methanol 
• 1374863-09-8 2-(trifluoromethyl)-6-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one 
• 1374864-32-0 6-(2-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)propyl)-2-(trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one 
• 676534-17-1 N-cyclobutyl-2-methyl-6-(trifluoromethyl)nicotinamide 
• 648421-70-9 1-methyl-4-{[2-methyl-6-(trifluoromethyl)-3-pyridinyl]carbonyl}-1,4-diazepane 
• 562106-02-9 5-Chloro-7-(4-methoxyphenyl)-2-trifluoromethyl-[1,6]naphthyridine 
• 261635-98-7 2-methyl-6-(trifluoromethyl)-3-pyridinecarbonyl chloride 
• 562106-01-8 7-(4-methoxyphenyl)-2-trifluoromethyl-[1,6]naphthyridin-5-ol 

Relevant articles and documents

NOVEL BRONCHODILATING HETERO-LINKED AMIDES

The invention relates to novel molecules having the general formula (I), and which molecules are useful to treat a disorder or disease characterized by bronchoconstriction, e.g. COPD and asthma inflammation and/or vasoconstriction, e.g. hypertension.

Insecticidal anthranilic diamides: A new class of potent ryanodine receptor activators

A novel class of anthranilic diamides has been discovered with exceptional insecticidal activity on a range of Lepidoptera. These compounds have been found to exhibit their action by release of intracellular Ca2+ stores mediated by the ryanodine receptor. The discovery, synthesis, structure-activity, and biological results are presented.