56226-07-4Relevant academic research and scientific papers
Synthesis and biological evaluation of coumarincarboxylic acids as inhibitors of gyrase B. L-rhamnose as an effective substitute for L-noviose
Ferroud, Didier,Collard, Jeannine,Klich, Michel,Dupuis-Hamelin, Claudine,Mauvais, Pascale,Lassaigne, Patrice,Bonnefoy, Alain,Musicki, Branislav
, p. 2881 - 2886 (2007/10/03)
A series of novobiocin-like coumarincarboxylic acids has been prepared bearing the L-rhamnosyl moiety as the sugar portion of the molecule. The similar DNA gyrase inhibitory activity of the novel class of coumarins to that of novobiocin demonstrates that L-rhamnose can effectively replace L-novoise. Introduction of alkyl side-chains at C-5 of coumarin leads to improved in vitro antibacterial properties in the novel series.
Cannabis XVIII. Isolation and synthesis of olivetol derivatives formed in the pyrolysis of cannabidiol
Luteyn,Spronck,Salemink
, p. 187 - 190 (2007/10/13)
Pyrolysis of cannabidiol results in the formation of several new cannabinoids and cracking products. In an earlier paper several structures were proposed for the cracking products based on GCMS measurements. In this paper the isolation and synthesis of the majority of these cracking products - which are in general C2-substituted olivetol derivatives - is described. 2,6-Dimethoxy-4-pentylphenyl-lithium and the cuprates derived therefrom proved to be very promising intermediates for the synthesis of olivetol derivatives specifically substituted at C2. The versatility of these reagents is illustrated by several examples.
