56247-43-9Relevant academic research and scientific papers
NEW SYNTHESES OF α-AMINO ACIDS BASED ON N-ACYLIMINO ACETATES
Bretschneider, Thomas,Miltz, Wolfgang,Muenster, Peter,Steglich, Wolfgang
, p. 5403 - 5414 (2007/10/02)
The reaction of N-acylamino-2-bromoacetates 2 ( via N-acylimino acetates 3 ) with higher order mixed cuprates, trimethylsilyl enol ethers and β-dicarbonyl compounds leads to a variety of α-amino acid derivatives.Their conversion into the free amino acids can be conveniently carried out by the use of t-butyl protection.In case of the N-acetyl compounds cleavage of the protecting group and optical resolution can be achieved in one step hog renal acylase.
SYNTHESIS OF α-AMINO ACID DERIVATIVES BY COPPER(I)-CATALYZED CONJUGATE ADDITION OF GRIGNARD REAGENTS TO METHYL 2-ACETAMIDOACRYLATE
Cardellicchio, C.,Fiandanese, V.,Marchese, G.,Naso, F.,Ronzini, L.
, p. 4387 - 4390 (2007/10/02)
The reactions of Grignard reagent with methyl 2-acetamidoacrylate in the presence of CuI give fair to good yields of α-amino esters; the corresponding α-deutero- or α-methyl-derivatives are obtained upon quenching with D+ or CH3I, respectively.
