56269-49-9Relevant academic research and scientific papers
Making Copper(0) Nanoparticles in Glycerol: A Straightforward Synthesis for a Multipurpose Catalyst
Dang-Bao, Trung,Pradel, Christian,Favier, Isabelle,Gómez, Montserrat
, p. 2832 - 2846 (2017/08/23)
Small zero-valent copper nanoparticles (CuNPs) have been straightforwardly prepared from Cu(I) and Cu(II) precursors in glycerol and in the presence of polyvinylpyrrolidone as stabilizer. Thanks to the negligible vapor pressure of the solvent, these original nano-systems could be directly characterized in glycerol as well as in the solid state, exhibiting relevantly homogeneous colloidal dispersions, also even after catalysis. CuNPs coming from the well-defined coordination complex di-μ-hydroxobis[(N,N,N′,N′-tetramethylethylenediamine)copper(II)] chloride {[Cu(κ2-N,N-TMEDA)(μ-OH)]2Cl2} have been highly efficient in C–C and C–heteroatom bond formation processes. This new catalytic system has proved its performance in C–N couplings and in the synthesis of differently substituted propargylic amines through cross-dehydrogenative couplings, multi-component reactions such as A3 (aldehyde-alkyne-amine) and KA2 (ketone-alkyne-amine) couplings, as well as in the formation of heterocycles such as benzofurans, indolizines, and quinolines under smooth conditions. No significant copper amount was detected in the extracted organic compounds from the catalytic phase by inductively coupled plasma-atomic emission spectroscopic (ICP-AES) analyses, proving a highly efficient immobilization of copper nanoparticles in glycerol. From a mechanistic point of view, spectroscopic data (infrared and ultraviolet-visible spectra) agree with a surface-like catalytic reactivity. (Figure presented.).
Oxidative coupling of N,N-Dialkylanilines using iodic acid and sodium nitrite
Huddar, Sameerana N.,Mahajan, Ulhas S.,Akamanchi, Krishnacharya G.
experimental part, p. 808 - 809 (2011/01/07)
A new reagent system, a combination of iodic acid and sodium nitrite has been investigated for oxidative coupling of N,N-disubstituted anilines. A facile para-selective coupling occurs to give benzidines at room temperature in water as a solvent. A tentative mechanism is proposed with some supporting experiments.
Ce(SO4)2-mediated nitration of N,N-dialkylanilines with NaNO2 in water
Yang, Xianghua,Xi, Chanjuan
, p. 3381 - 3392 (2008/02/12)
Ce(SO4)2-mediated nitration of N,N-dialkylanilines with NaNO2 using water as the solvent has been achieved in good to excellent yields. The nitrating reaction proceeded smoothly at ambient temperature. Copyright Taylor & Francis Group, LLC.
Regioselective nitration of N,N-dialkylanilines using cerium(IV) ammonium nitrate in acetonitrile
Yang, Xianghua,Xi, Chanjuan,Jiang, Yanfeng
, p. 8781 - 8783 (2007/10/03)
A highly regioselective and inexpensive nitration of N,N-dialkylanilines by cerium(IV) ammonium nitrate (CAN) in acetonitrile under room temperature to yield p-nitryl-N,N-dialkylanilines in good yields was reported.
Aminoalkyl-substituted aromatic bicyclic compounds, methods for their preparation and their use as pharmaceuticals
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, (2008/06/13)
The present invention relates to aminoalkyl-substituted aromatic bicyclic compounds of formula I, which are valuable pharmaceutically active compounds that are suitable, for example, for the treatment of obesity, type II diabetes, arteriosclerosis, high blood pressure, paresthesia, depression, anxiety, anxiety neuroses, schizophrenia, disorders associated with the circadian rhythm, and drug abuse, as well as normalizing lipid metabolism.
N-Dealkylation-N-nitrosation of Tertiary Aromatic Amines by n-Butyl Nitrite
Verardo, Giancarlo,Giumanini, Angelo G.,Strazzolini, Paolo
, p. 7845 - 7852 (2007/10/02)
N,N-Dialkyl aromatic amines with a variety of ring substituents are N-dealkylated and N-nitrosated efficiently by n-butyl nitrite/ammonium chloride/water at reflux temperature.Ring nitrosation was never observed, but minor amounts of m- and p-nitro amines and/or nitrosamines were formed in some cases.Ring nitration is rather a reaction of the initial substrate than a process occurring on formed nitrosamines.The leaving propensities of the initial N-substituents to yield nitrosamines were in the order benzyl >> methyl >> alkyl.Key Words: Nitrosamines; N-Dealkylation; N-Nitrosation; C-Nitration; Alkyl nitrite.
