562812-95-7

Basic information

• Product Name: Propanedioic acid, [[4-(2-bromoethoxy)phenyl]methylene]-, diethyl ester
• CAS NO: 562812-95-7
• Molecular Formula: C16H19BrO5
• Molecular Weight: 371.228
• Mol File: 562812-95-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, [[4-(2-bromoethoxy)phenyl]methylene]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, [[4-(2-bromoethoxy)phenyl]methylene]-, diethyl ester(562812-95-7)
• EPA Substance Registry System: Propanedioic acid, [[4-(2-bromoethoxy)phenyl]methylene]-, diethyl ester(562812-95-7)

Safety Data

• Hazardous Substances Data: 562812-95-7(Hazardous Substances Data)

Upstream product

• 52191-15-8 4-(2-bromoethyloxy)benzaldehyde 
• 105-53-3 diethyl malonate 

Downstream Products

• 562812-96-8 diethyl 2-{4-[2-(2-carboxy-3-dodecanoylindol-1-yl)ethoxy]benzylidene}malonate 

Relevant articles and documents

Structure-Activity Relationship Studies of 1-Substituted 3-Dodecanoylindole-2-carboxylic Acids as Inhibitors of Cytosolic Phospholipase A2-Mediated Arachidonic Acid Release in Intact Platelets

A series of 3-dodecanoylindole-2-carboxylic acid derivatives with varied carboxylic acid substituents at the indole 1-position were synthesized and evaluated for their ability to inhibit arachidonic acid release in human platelets mediated by the cytosolic phospholipase A2. Structure-activity relationship studies revealed that increasing the polarity of these substituents by the introduction of additional polar groups in the proximity of the carboxylic acid moiety reduced activity. Conformational restriction of the indole-1-carboxylic acid substituents in distinct positions as well as extending the length of these residues led to compounds which did not substantially differ in their potencies.