562858-22-4

Upstream product

• 100-39-0 benzyl bromide 
• 474915-71-4 (2S,3S)-methyl 2,3-O-isopropylidene-2-[(S)-1-hydroxy-3-phenyl-2-propynyl]pentanoate 
• 562858-24-6 (4R,5S)-4-((S)-1-Benzyloxy-3-phenyl-prop-2-ynyl)-5-ethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid 
• 562858-23-5 (4R,5S)-4-((S)-1-Benzyloxy-3-phenyl-prop-2-ynyl)-5-ethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester 

Downstream Products

• 562858-26-8 (4S,5R,9R)-8-Benzoyl-9-benzyloxy-4-ethyl-8-hydroxy-2,2-dimethyl-6-oxo-1,3-dioxa-7-aza-spiro[4.4]nonane-7-carboxylic acid tert-butyl ester 
• 562858-25-7 [(4R,5S)-4-((S)-1-Benzyloxy-3-phenyl-prop-2-ynyl)-5-ethyl-2,2-dimethyl-[1,3]dioxolane-4-carbonyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Asymmetric total synthesis of pseurotin A

(Matrix presented) The asymmetric total syntheses of pseurotin A and 8-O-demethylpseurotin A have been accomplished. Key reactions are a NaH-promoted intramolecular cyclization of an alkynylamide to form a γ-lactam, an aldol reaction of a benzylidene-subs