56307-98-3Relevant academic research and scientific papers
Synthesis and antifungal activities of a series of (1,2-disubstituted vinyl)imidazoles
Ogawa,Matsuda,Eto,Asaoka,Kuraishi,Iwasa,Nakashima,Yamaguchi
, p. 2301 - 2307 (2007/10/02)
A series of vinylimidazoles containing a hetero atom such as sulfur or oxygen at a β-position of the vinyl group was prepared and the antifungal activities were tested. It was found that sulfur-substituted derivatives such as (E)-1-[2-(methylthio)-1-[2-(p
Conjugate addition to 3-(ptolylsulphinyl)chromone: A route to 2-substituted chromones and chiral substituted chroman-4-ones
Saengchantara, Suthiweth T.,Wallace, Timothy W.
, p. 6553 - 6564 (2007/10/02)
3-(p-Tolylsulphinyl)chromone 3a undergoes diastereoselective conjugate addition of lithium dimethylcuprate, producing a mixture of 2-methyl-3-(p-tolylsulphinyl)chroman-4-ones. Heating the mixture to 140°C gives 2-methylchromone in quantitative yield. Desulphurisation of the mixed products from (S)-3a gives (S)-2-methylchroman-4-one with 90% e.e. Chelation of the carbonyl and sulphoxide oxygens during methyl addition accounts for the diastereo selection.
