56309-62-7

Basic information

• Product Name: 2,5-DIMETHOXYPHENYL ISOCYANATE
• Synonyms: 2,5-DIMETHOXYPHENYL ISOCYANATE;Benzene, 2-isocyanato-1,4-dimethoxy- (9CI);2-isocyanato-1,4-dimethoxybenzene
• CAS NO: 56309-62-7
• Molecular Formula: C₉H₉NO₃
• Molecular Weight: 179.17
• Product Categories: ISOCYANATE;Isocyanates;Nitrogen Compounds;Organic Building Blocks
• Mol File: 56309-62-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 39-40°C
• Boiling Point: 152-154°C 26mm
• Flash Point: >110°C
• Appearance: /
• Density: 1.2822 (rough estimate)
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.5600 (estimate)
• Sensitive: Moisture Sensitive
• BRN: 3267303
• CAS DataBase Reference: 2,5-DIMETHOXYPHENYL ISOCYANATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIMETHOXYPHENYL ISOCYANATE(56309-62-7)
• EPA Substance Registry System: 2,5-DIMETHOXYPHENYL ISOCYANATE(56309-62-7)

Safety Data

• Hazard Codes: Xn
• Statements: 20/22-36/37/38-42-20/21/22
• Safety Statements: 22-26-36/37/39-45
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 56309-62-7(Hazardous Substances Data)

Usage

General Description

2,5-DIMETHOXYPHENYL ISOCYANATE is a chemical compound with the molecular formula C9H9NO3. It is a derivative of isocyanate, which is widely used in the production of polyurethane foams, adhesives, coatings, and elastomers. 2,5-DIMETHOXYPHENYL ISOCYANATE is known for its reactivity and ability to form strong bonds with a variety of substances. It is commonly used in industrial applications, specifically in the manufacturing of polyurethane products. However, it is important to handle this chemical with caution, as it can be hazardous if not properly handled and managed.

InChI:InChI=1/C9H9NO3/c1-12-7-3-4-9(13-2)8(5-7)10-6-11/h3-5H,1-2H3

Upstream product

• 2150-40-5 methyl 2,5-dimethoxybenzoate 
• 2785-98-0 2,5-dimethoxybenzoic acid 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 102-56-7 2,5-dimethoxyaniline 
• 2100-42-7 2-chloro-1,4-dimethoxybenzene 
• 917-61-3 sodium isocyanate 
• 75-44-5 phosgene 

Downstream Products

• 220844-32-6 1-(2,5-dimethoxyphenyl)-3-quinolin-4-ylurea 
• 118487-96-0 5-hydroxy-4-[(2,5-dimethoxyphenyl)ureylene]-7-methylthieno[2,3-c]pyridine 
• 1262526-89-5 N-acetyl-S-(2,5-dimethoxyphenylcarbamoyl)cysteine 
• 1233485-29-4 C₂₀H₂₁ClN₄O₄ 
• 500594-46-7 C₂₀H₂₂N₄O₄ 
• 501679-24-9 1-(2,5-dimethoxyphenyl)-3-(thiazol-2-yl)urea 
• 102-56-7 2,5-dimethoxyaniline 
• 1393556-58-5 C₁₅H₁₆N₂O₄ 
• 1450730-22-9 C₁₈H₂₃N₃O₅S 
• 1240-72-8 1,3-bis(2,5-dimethoxyphenyl)urea 
• 114559-66-9 1-(2,5-Dimethoxy-phenyl)-3-((1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-urea 
• 120958-86-3 1-(2,5-Dimethoxy-phenyl)-3-[3-(3-piperidin-1-ylmethyl-phenoxy)-propyl]-urea 
• 23121-89-3 (2,5-Dimethoxy-phenyl)-carbamic acid 3-methoxycarbonylamino-phenyl ester 

Relevant articles and documents

Synthesis and in vitro anti-bladder cancer activity evaluation of quinazolinyl-arylurea derivatives

Based on the structural modification of molecular-targeted agent sorafenib, a series of quinazolinyl-arylurea derivatives were synthesized and evaluated for their anti-proliferative activities against six human cancer cell lines. Compared with other cell lines tested, T24 was more sensitive to most compounds. Compound 7j exhibited the best profile with lower IC50 value and favorable selectivity. In this study, we focused on 7j-induced death forms of T24 cells and tried to elucidate the reason for its potent proliferative inhibitory activity. Compound 7j treatment could trigger three different cell death forms including apoptosis, ferroptosis, and autophagy; which form would occur depended on the concentrations and incubation time of 7j: (1) Lower concentrations within the initial 8 h of 7j treatment led to apoptosis-dependent death. (2) Ferroptosis and autophagy occurred in the case of higher concentrations combining with extended incubation time through effectively regulating the Sxc?/GPx4/ROS and PI3K/Akt/mTOR/ULK1 pathways, respectively. (3) The above death forms were closely associated with intracellular ROS generation and decreased mitochondrial membrane potential induced by 7j. In molecular docking and structure-activity relationship analyses, 7j could bind well to the active site of the corresponding receptor glutathione peroxidase 4 (GPx4). Compound 7j could be a promising lead for molecular-targeted anti-bladder cancer agents’ discovery.

1-(2,5-dimethoxyphenyl)-3-(substituted pyrimidine-4-yl)urea compound and preparation and application thereof

The invention discloses a 1-(2,5-dimethoxyphenyl)-3-(substituted pyrimidine-4-yl)urea compound and preparation and application thereof. The compound has no toxicity function on the proliferation of BEAS-2B cells (lung normal cells), but has certain inhibi

A simple and efficient synthesis of diaryl ureas with reduction of the intermediate isocyanate by triethylamine

Thirty symmetrical diaryl urea derivatives were synthesised in moderate to excellent yields from arylamine and triphosgene with triethylamine as a reducing agent for the intermediate, isocyanate. It was significant that part of the products could be collected in almost quantitative yield without column chromatography. The procedure under mild reaction conditions was tolerant of a wide range of functional groups. The structures of the compounds were determined by NMR, MS and X-ray crystallographic analyses.