56309-62-7

Usage

Uses

Used in the Polyurethane Industry:
2,5-DIMETHOXYPHENYL ISOCYANATE is used as a key ingredient in the production of polyurethane materials for its ability to create strong, durable, and versatile products. It contributes to the formation of polyurethane foams, which are utilized in various applications such as insulation, cushioning, and upholstery. Additionally, it is employed in the creation of adhesives, coatings, and elastomers, where its bonding strength and reactivity are critical for performance and durability.

InChI:InChI=1/C9H9NO3/c1-12-7-3-4-9(13-2)8(5-7)10-6-11/h3-5H,1-2H3

Upstream product

• 2100-42-7 2-chloro-1,4-dimethoxybenzene 
• 917-61-3 sodium isocyanate 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 102-56-7 2,5-dimethoxyaniline 
• 2785-98-0 2,5-dimethoxybenzoic acid 
• 2150-40-5 methyl 2,5-dimethoxybenzoate 
• 75-44-5 phosgene 

Downstream Products

• 23121-89-3 (2,5-Dimethoxy-phenyl)-carbamic acid 3-methoxycarbonylamino-phenyl ester 
• 120958-86-3 1-(2,5-Dimethoxy-phenyl)-3-[3-(3-piperidin-1-ylmethyl-phenoxy)-propyl]-urea 
• 118488-00-9 6-hydroxy-7-[(2,5-dimethoxyphenyl)ureylene]-4-methylthieno[3,2-c]pyridine 
• 118487-96-0 5-hydroxy-4-[(2,5-dimethoxyphenyl)ureylene]-7-methylthieno[2,3-c]pyridine 
• 1119859-81-2 3-amino-N-(2,5-dimethoxyphenyl)-1H-indazole-1-carboxamide 
• 1262526-89-5 N-acetyl-S-(2,5-dimethoxyphenylcarbamoyl)cysteine 
• 501679-24-9 1-(2,5-dimethoxyphenyl)-3-(thiazol-2-yl)urea 
• 1616260-80-0 N-(2,5-dimethoxyphenyl)-2-(4-nitro-1H-pyrrole-2-carbonyl)hydrazinecarboxamide 
• 1616260-90-2 N-(2,5-dimethoxyphenyl)-2-(1-methyl-4-nitro-1H-pyrrole-2-carbonyl)hydrazinecarboxamide 
• 1240-72-8 1,3-bis(2,5-dimethoxyphenyl)urea 

Relevant academic research and scientific papers

Synthesis and in vitro anti-bladder cancer activity evaluation of quinazolinyl-arylurea derivatives

Based on the structural modification of molecular-targeted agent sorafenib, a series of quinazolinyl-arylurea derivatives were synthesized and evaluated for their anti-proliferative activities against six human cancer cell lines. Compared with other cell lines tested, T24 was more sensitive to most compounds. Compound 7j exhibited the best profile with lower IC50 value and favorable selectivity. In this study, we focused on 7j-induced death forms of T24 cells and tried to elucidate the reason for its potent proliferative inhibitory activity. Compound 7j treatment could trigger three different cell death forms including apoptosis, ferroptosis, and autophagy; which form would occur depended on the concentrations and incubation time of 7j: (1) Lower concentrations within the initial 8 h of 7j treatment led to apoptosis-dependent death. (2) Ferroptosis and autophagy occurred in the case of higher concentrations combining with extended incubation time through effectively regulating the Sxc?/GPx4/ROS and PI3K/Akt/mTOR/ULK1 pathways, respectively. (3) The above death forms were closely associated with intracellular ROS generation and decreased mitochondrial membrane potential induced by 7j. In molecular docking and structure-activity relationship analyses, 7j could bind well to the active site of the corresponding receptor glutathione peroxidase 4 (GPx4). Compound 7j could be a promising lead for molecular-targeted anti-bladder cancer agents’ discovery.

1-(2,5-dimethoxyphenyl)-3-substituted ureas colon cancer inhibitor, and preparation method and application thereof

The invention discloses a 1-(2,5-dimethoxyphenyl)-3-substituted ureas compound capable of acting on colon cancer, and a preparation method and application thereof. The 1-(2,6-dichlorophenyl)-3-(6-(substituted benzylamino)pyrimidine-4-yl)ureas compound dis

1-(2,5-dimethoxyphenyl)-3-(substituted pyrimidine-4-yl)urea compound and preparation and application thereof

The invention discloses a 1-(2,5-dimethoxyphenyl)-3-(substituted pyrimidine-4-yl)urea compound and preparation and application thereof. The compound has no toxicity function on the proliferation of BEAS-2B cells (lung normal cells), but has certain inhibi

With anti-tumor effect of a quinazoline-urea derivative and its application (by machine translation)

The present invention relates to a of the general formula (II) anti-tumor function of said quinazoline-urea derivative and its application. The definition of the substituent in the general formula (II) in the specification. This invention, in order to SUO draw non-Buddhist nun and Geftinat compounds as the precursor, retention of SUO draw non-Buddhist nun the pharmocology-carbamido; at the same time, such as in reserved [...] EGFR-TKIs Geftinat, synthesis, and obtain a series of quinazoline-urea derivatives, by the in vitro activity tests, some compounds exhibit excellent anti-tumor activity, such derivatives have high research and utility value. (II). (by machine translation)

A simple and efficient synthesis of diaryl ureas with reduction of the intermediate isocyanate by triethylamine

Thirty symmetrical diaryl urea derivatives were synthesised in moderate to excellent yields from arylamine and triphosgene with triethylamine as a reducing agent for the intermediate, isocyanate. It was significant that part of the products could be collected in almost quantitative yield without column chromatography. The procedure under mild reaction conditions was tolerant of a wide range of functional groups. The structures of the compounds were determined by NMR, MS and X-ray crystallographic analyses.

Palladium-catalyzed cross-coupling of aryl chlorides and triflates with sodium cyanate: A practical synthesis of unsymmetrical ureas

An efficient method for palladium-catalyzed cross-coupling of aryl chlorides and triflates with sodium cyanate is reported. The protocol allows for the synthesis of unsymmetrical N,N'-di- and N,N,N'-trisubstituted ureas in one pot and is tolerant of a wide range of functional groups. Insight into the mechanism of aryl isocyanate formation was gleaned through studies of the transmetalation and reductive elimination steps of the reaction, including the first demonstration of reductive elimination from an arylpalladium isocyanate complex to produce an aryl isocyanate.

Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors

Ten azo compounds including azo-resveratrol (5) and azo-oxyresveratrol (9) were synthesized using a modified Curtius rearrangement and diazotization followed by coupling reactions with various phenolic analogs. All synthesized compounds were evaluated for their mushroom tyrosinase inhibitory activity. Compounds 4 and 5 exhibited high tyrosinase inhibitory activity (56.25% and 72.75% at 50 μM, respectively). The results of mushroom tyrosinase inhibition assays indicate that the 4-hydroxyphenyl moiety is essential for high inhibition and that 3,5-dihydroxyphenyl and 3,5-dimethoxyphenyl derivatives are better for tyrosinase inhibition than 2,5-dimethoxyphenyl derivatives. Particularly, introduction of hydroxyl or methoxy group into the 4-hydroxyphenyl moiety diminished or significantly reduced mushroom tryosinase inhibition. Among the synthesized azo compounds, azo-resveratrol (5) showed the most potent mushroom tyrosinase inhibition with an IC50 value of IC50 = 36.28 ± 0.72 μM, comparable to that of resveratrol, a well-known tyrosinase inhibitor.

5-Hydroxytryptamine (5-HT3) Receptor Antagonists. 3. Ortho-Substituted Phenylureas

A novel series of potent 5-HT3 receptor antagonists, ortho-substituted phenylureas 6a-z, is described in which the 5-membered ring of the previously reported indazoles and indolines has been replaced by an intramolecular hydrogen bond.High potency was found both for carbamate 6a and urea 6b.Granatane 6c was less potent than the equivalent tropane.Phenylurea 11c lacking the ortho substituent was inactive.Whereas further substitution could not be tolerated in the aromatic ring, activity was retained with a range of O-alkyl groups, compounds 6k-t.In addition, good activity was found for ortho ester 6u and sulfonamide 6x.The ortho-substituted phenylureas can therefore be regarded as bioisosteres of the 6,5-heterocycles indole, indazole, and indoline.