5632-73-5

Basic information

• Product Name: rac-5-amino-5-phenyl-piperidin-2-one
• Synonyms: rac-5-amino-5-phenyl-piperidin-2-one
• CAS NO: 5632-73-5
• Molecular Weight: 190.245
• Mol File: 5632-73-5.mol

Chemical Properties

• CAS DataBase Reference: rac-5-amino-5-phenyl-piperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: rac-5-amino-5-phenyl-piperidin-2-one(5632-73-5)
• EPA Substance Registry System: rac-5-amino-5-phenyl-piperidin-2-one(5632-73-5)

Safety Data

• Hazardous Substances Data: 5632-73-5(Hazardous Substances Data)

Upstream product

• 22049-87-2 rac-4-nitro-4-phenyl-butyric acid methyl ester 
• 622-42-4 1-nitro-1-phenylmethane 
• 1236302-97-8 rac-5-nitro-5-phenyl-piperidin-2-one 

Downstream Products

• 1236303-73-3 rac-2-methoxy-N-(3-phenyl-piperidin-3-yl)-4,6-bis-trifluoromethyl-benzamide 
• 1558682-36-2 rac-3-(2-methoxy-4-methyl-6-trifluoromethyl-benzoylamino)-3-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 1558682-35-1 rac-3-amino-3-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 1558680-89-9 rac-N-(1-methanesulfonyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethylbenzamide 
• 1558680-86-6 rac-N-(1-benzoyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide 
• 1558680-84-4 rac-N-(1-acetyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bistrifluoromethyl-benzamide 
• 1558680-83-3 rac-N-(1-benzyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide 
• 1236302-24-1 rac-N-(1-cyclopropylmethyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethylbenzamide 
• 1236302-23-0 rac-N-(1-cyclopentyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethylbenzamide 
• 1236303-77-7 rac-N-(1-isopropyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide 
• 1236303-76-6 rac-N-(1-ethyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide 

Relevant articles and documents

3-amido-3-aryl-piperidines: A novel class of potent, selective, and orally active GlyT1 inhibitors

3-Amido-3-aryl-piperidines were discovered as a novel structural class of GlyT1 inhibitors. The structure-activity relationship, which was developed, led to the identification of highly potent compounds exhibiting excellent selectivity against the GlyT2 isoform, drug-like properties, and in vivo activity after oral administration.

PIPERIDINE DERIVATIVES

The present invention relates to a compound of formula I wherein R1, R2, and Ar are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical iso