1558680-89-9

Upstream product

• 1558682-36-2 rac-3-(2-methoxy-4-methyl-6-trifluoromethyl-benzoylamino)-3-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 1558682-35-1 rac-3-amino-3-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 1236302-98-9 rac-3-phenyl-piperidin-3-yl-amine 
• 5632-73-5 rac-5-amino-5-phenyl-piperidin-2-one 
• 1236302-97-8 rac-5-nitro-5-phenyl-piperidin-2-one 
• 22049-87-2 rac-4-nitro-4-phenyl-butyric acid methyl ester 
• 622-42-4 1-nitro-1-phenylmethane 
• 1236303-73-3 rac-2-methoxy-N-(3-phenyl-piperidin-3-yl)-4,6-bis-trifluoromethyl-benzamide 
• 124-63-0 methanesulfonyl chloride 

Relevant academic research and scientific papers

3-amido-3-aryl-piperidines: A novel class of potent, selective, and orally active GlyT1 inhibitors

3-Amido-3-aryl-piperidines were discovered as a novel structural class of GlyT1 inhibitors. The structure-activity relationship, which was developed, led to the identification of highly potent compounds exhibiting excellent selectivity against the GlyT2 isoform, drug-like properties, and in vivo activity after oral administration.