5633-36-3

Basic information

• Product Name: [3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanone
• CAS NO: 5633-36-3
• Molecular Formula: C₁₅H₁₁NO₄
• Molecular Weight: 269.2521
• Mol File: 5633-36-3.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 456°C at 760 mmHg
• Flash Point: 208.8°C
• Density: 1.364g/cm³
• Vapor Pressure: 1.68E-08mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: [3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanone(5633-36-3)
• EPA Substance Registry System: [3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanone(5633-36-3)

Safety Data

• Hazardous Substances Data: 5633-36-3(Hazardous Substances Data)

Usage

Description

[3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanone, also known as nitrophenylpropiophenone epoxide, is an organic compound with the molecular formula C15H11NO4. It is an epoxide derivative featuring a phenyl ring connected to an oxirane ring with a nitro group and a ketone group. [3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanone is recognized for its versatile chemical properties, making it a valuable precursor in the synthesis of pharmaceuticals and other organic compounds.

Uses

Used in Pharmaceutical Synthesis:
[3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanone is used as a precursor in the pharmaceutical industry for the synthesis of various drugs. Its unique structure and reactivity allow for the creation of a wide range of medicinal compounds, contributing to the development of novel treatments for different health conditions.
Used in Organic Chemistry Research:
In the field of organic chemistry, [3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanone serves as a key intermediate for the synthesis of complex organic molecules. Its epoxide and nitro group functionalities enable it to participate in various chemical reactions, such as ring-opening and reduction, making it a valuable tool for researchers in organic chemistry.
Used in Chemical Intermediates Production:
[3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanone is also utilized as a chemical intermediate in the production of other organic compounds. Its ability to undergo various chemical transformations makes it a useful building block for creating a diverse array of molecules with potential applications in different industries, such as agriculture, materials science, and the chemical industry.

Upstream product

• 2960-55-6 (E)-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one 
• 1222-98-6 4-nitrochalcone 
• 555-16-8 4-nitrobenzaldehdye 
• 98-86-2 acetophenone 
• 532-27-4 1-chloroacetophenone 
• 619-73-8 4-nitrobenzyl chloride 
• 4636-16-2 iodoacetophenone 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 766-76-7 benzoate 
• 71-47-6 formate 
• 555-16-8 4-nitrobenzaldehdye 
• 1431527-16-0 C₁₅H₁₂ClNO₄ 
• 1431527-03-5 C₂₄H₁₈ClNO₅ 
• 1217439-19-4 C₂₃H₁₈N₂O₄ 
• 28710-59-0 5-(4-nitrophenyl)-1,3-diphenylpyrazole 
• 3672-50-2 5-(4-nitrophenyl)-3-phenylisoxazole 

Relevant articles and documents

Application of chiral TADDOL ligand and rare earth metal amide in combined catalysis of asymmetric reaction

The invention relates to application of chiral TADDOL ligand and rare earth metal amide in combined catalysis of asymmetric epoxidation reaction of chalcone compounds. According to the application, alpha, beta-unsaturated ketone shown in a formula (1) and tert-butyl hydroperoxide react in the presence of organic alkali under the combined catalytic action of a chiral TADDOL ligand shown in a formula (3) and rare earth metal amide in an anhydrous, oxygen-free and protective atmosphere to obtain the chiral epoxy compound shown in the formula (2) after the reaction is completed, wherein R1 is selected from hydrogen, alkyl, halogen, alkoxy, trifluoromethyl, nitro or cyano, R2 is selected from phenyl, substituted phenyl, naphthyl, furyl or thienyl; R3 and R4 are respectively and independently selected from alkyl, phenyl or R3 and R4 and carbon atoms connected with R3 and R4 form naphthenic base; Ar is phenyl, substituted phenyl, biphenyl or naphthyl; the molecular formula of the rare earth metal amide is RE [N (SiMe3) 2] 3. The method has the advantages of wide substrate application range, high yield and high enantioselectivity.

Facile epoxidation of α, β-unsaturated ketones with urea-2,2-dihydroperoxypropane as a new oxidant

Abstract: Various aromatic α, β-unsaturated ketones were successfully transformed into their corresponding epoxides using urea-2,2-dihydroperoxypropane as the oxygen source for the first time. The reactions were carried out under mild alkaline conditions at room temperature in high yields and short reaction times. Graphical Abstract: [Figure not available: see fulltext.]

A highly enantioselective asymmetric Darzens reaction catalysed by proline based efficient organocatalysts for the synthesis of di- and tri-substituted epoxides

A new class of easily available and readily tunable proline based chiral organocatalysts was found to efficiently catalyse an unprecedented highly enantioselective asymmetric Darzens reaction of α-chloroketones and substituted α-chloroketones with various