56344-32-2

Usage

Uses

Used in Pharmaceutical Industry:
N-(3-HYDROXYPROPYL)ETHYLENEDIAMINE is used as an impurity in the synthesis of [application type] for [application reason] Fasudil (F150018), a selective ROCK inhibitor. Its presence in the synthesis process is significant as it may affect the purity and efficacy of the final product, Fasudil, which is utilized in the treatment of various medical conditions.
Used in Research and Development:
N-(3-HYDROXYPROPYL)ETHYLENEDIAMINE is used as a research compound for [application type] in the study and development of [application reason] new drugs and therapies involving ROCK inhibitors. Understanding the properties and interactions of this impurity can help researchers optimize the synthesis process and improve the overall effectiveness of Fasudil and related compounds.
Used in Quality Control and Analysis:
N-(3-HYDROXYPROPYL)ETHYLENEDIAMINE is used as a reference material for [application type] in quality control and analytical testing of [application reason] Fasudil and other ROCK inhibitors. By comparing the properties and behavior of this impurity with those of the active pharmaceutical ingredient, quality control teams can ensure the purity and consistency of the final product, ensuring patient safety and therapeutic efficacy.

InChI:InChI=1/C5H14N2O/c6-2-4-7-3-1-5-8/h7-8H,1-6H2

Upstream product

• 107-15-3 ethylenediamine 
• 627-18-9 1-bromo-3-propanol 
• 75-56-9 methyloxirane 
• 503-30-0 trimethylene oxide 

Downstream Products

• 752238-67-8 N-(5-hydroxy-3-azahexyl)-4-nitrobenzamide 
• 192379-57-0 (3-Hydroxy-propyl)-[2-(2-nitro-benzenesulfonylamino)-ethyl]-carbamic acid tert-butyl ester 
• 192379-50-3 {2-[(6-Aminomethyl-pyridin-2-ylmethyl)-(2-nitro-benzenesulfonyl)-amino]-ethyl}-(3-hydroxy-propyl)-carbamic acid tert-butyl ester 
• 851936-04-4 copper(II) N-(2-aminoethyl)-3-amino-1-propanol (μ-terephthalate) 
• 192379-47-8 C₄₄H₅₄N₄O₉ 
• 192379-49-0 {2-[[6-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-pyridin-2-ylmethyl]-(2-nitro-benzenesulfonyl)-amino]-ethyl}-(3-hydroxy-propyl)-carbamic acid tert-butyl ester 
• 192379-55-8 N-[2-(3-Hydroxy-propylamino)-ethyl]-2-nitro-benzenesulfonamide 

Relevant academic research and scientific papers

Production process of hydroxyethyl/propylethylenediamine

The invention provides a production process of hydroxyethyl/propyl ethylenediamine, which comprises the following steps: A) conveying ethylenediamine and epoxy ethyl/propane to a mixing unit through a continuous conveying unit for mixing to obtain a mixed solution; b) conveying the mixed solution to a reaction unit for reaction to obtain a reaction solution; the reaction temperature is 80-200 DEG C) conveying the reaction liquid to a rectification unit, and separating the unreacted raw material ethylenediamine to obtain the hydroxyethyl/propyl ethylenediamine product. According to the production method of hydroxyethyl/propylethylenediamine provided by the invention, ethylene oxide/propane and ethylenediamine are mixed and react in a liquid state, so that the volume ratio of ethylene oxide/propane and ethylenediamine is reduced, the production efficiency is remarkably improved, and energy waste caused by vaporization heat absorption before ethylene oxide/propane participates in the reaction is avoided.

Method and apparatus for sunless tanning

Apparatus for simulating skin tanning comprises a receptacle containing a fluid comprising dihydroxyacetone, a receptacle containing a fluid comprising a secondary polyamine, and dispensing means for simultaneously or sequentially providing desired amounts of dihydroxyacetone and polyamine.

NUCLEOPHILIC CLEAVAGE AND FORMATION OF SATURATED HETEROCYCLES. XII. REACTIVITY OF SMALL HETEROCYCLES TOWARD AMINOLYSIS AND HYDROLYSIS

The cleavage of four-membered saturated heterocycles proceeds via a more product-like transition state than that of three-membered rings.General acid catalysis is characteristic of oxygen heterocycles, but in the case of nitrogen heterocycles catalysis is specific.The reactivity of amines in the cleavage of azetidines is linearly dependent on their pKa values, primary and secondary amines comprising separate reaction series.