5635-30-3

Upstream product

• 613-90-1 benzoyl cyanide 
• 1864-93-3 N,N-dimethyl-p-phenetidine 
• 536-74-3 phenylacetylene 
• 61587-14-2 N-(4-ethoxyphenyl)formamide 
• 77-78-1 dimethyl sulfate 
• 108-24-7 acetic anhydride 

Relevant academic research and scientific papers

Iron-Catalyzed Oxidation of 4-Substituted N,N-Dimethylanilines with Molecular Oxygen in the Presence of Benzoyl Cyanide

The oxidation of 4-substituted N,N-dimethylanilines with molecular oxygen using a catalytic amount of iron(III) chloride efficiently proceeded in the presence of benzoyl cyanide to give the corresponding N-cyanomethyl-N-methylanilines along with N-methylformanilides.

Copper-catalysed Oxidative Coupling of 4-Substituted N,N-Dimethylanilines with Terminal Alkynes under Molecular Oxygen

The reaction of 4-substituted N,N-dimethylanilines 1 with terminal alkynes 2 in presence of copper(II) chloride under oxygen gives the corresponding N-methyl-N-propargylaniline derivatives 3 together with N-methylformanilides 4 and N-methylanilines 5.

Oxidative Dealkylation of 4-Substituted N,N-Dialkylanilines with Molecular Oxygen in the Presence of Acetic Anhydride Promoted by Cobalt(II) or Copper(I) Chloride

The reaction of 4-substituted N,N-dimethylanilines 1a-d with acetic anhydride 5 proceeded efficiently in the presence of a catalytic amount of cobalt(II) or copper(I) chloride under oxygen to give the corresponding N-methylacetanilides 2a-d along with N-methylformanilides 3a-d.The reaction of N-alkyl-N-methyl-p-toluidines 1f-h with cobalt chloride revealed that the order of reactivity of the N-substituents follows the sequence allyl > benzyl >/= methyl > ethyl, while in the case of copper chloride the order was benzyl > allyl > methyl > ethyl.Aldehydes 18a-e and phenylglyoxylic acid derivatives 18f and 18g were obtained in fair to good yield from the reaction of n-substituted N-ethyl-p-toluidines 17a-g.

Cobalt(II) Chloride Catalyzed Oxidation of 4-Substituted N,N-Dialkylanilines with Molecular Oxygen in the Presence of Acetic Anhydride

The oxidation of 4-substituted N,N-dialkylanilines with molecular oxygen using a catalytic amount of cobalt(II) chloride efficiently proceeds in the presence of acetic anhydride to give N-alkylacetanilides in good yields along with N-alkylformanilides.