61587-14-2

Usage

Uses

Used in Pharmaceutical Industry:
4-Ethoxyphenylformamide is utilized as a building block for the synthesis of various drugs. Its unique chemical structure allows it to be a key component in the development of new pharmaceutical compounds, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Ethoxyphenylformamide serves as a precursor in the production of pesticides. Its role in the synthesis of agrochemicals aids in the development of effective pest control solutions, thereby supporting agricultural productivity and crop protection.

InChI:InChI=1/C9H11NO2/c1-2-12-9-5-3-8(4-6-9)10-7-11/h3-7H,2H2,1H3,(H,10,11)

Upstream product

• 64-18-6 formic acid 
• 156-43-4 4-Ethoxyaniline 
• 2258-42-6 formyl acetic anhydride 
• 109-94-4 formic acid ethyl ester 
• 107-31-3 Methyl formate 
• 124-38-9 carbon dioxide 
• 99358-57-3 4-ethoxy benzoyl azide 
• 619-86-3 4-(ethoxy)benzoic acid 
• 32459-62-4 4-ethoxyphenyl isocyanate 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 62-44-2 4-ethoxyacetanilide 
• 79377-23-4 N-[2-(1-ethyl-1H-[2]quinolyliden)-ethylidene]-p-phenetidine; hydriodide 
• 47174-66-3 N,N'-bis-(4-ethoxy-phenyl)-formamidine 
• 3154-18-5 N-methyl-p-phenetidine 
• 5635-30-3 N-Formyl-N-methyl-p-phenetidin 
• 61587-16-4 (4-Ethoxy-phenyl)-(4-nitro-3-trifluoromethyl-phenyl)-amine 
• 6943-24-4 (4-ethoxy-phenyl)-(2,4-dinitro-phenyl)-amine 
• 61587-17-5 (4-Ethoxy-phenyl)-(4-methyl-2-nitro-phenyl)-amine 
• 156-43-4 4-Ethoxyaniline 
• 18469-17-5 N-methyl-N-nitroso-p-phenetidine 
• 6628-28-0 6-ethoxy-2-methyl-quinoline 

Relevant academic research and scientific papers

Preparation method of formamide compound

The invention belongs to CO. 2 The invention relates to the technical field of activation conversion and related chemistry, and provides a preparation method of a formamide compound, which uses carbon dioxide. The amide compound and phenylsilane are used as raw materials, and the formamide compound is synthesized under the action of the nano porous palladium catalyst. The invention mainly provides a novel simple catalytic system and utilizes CO. 2 C1 The catalytic system has the advantages of mild reaction conditions, simple experiment operation, good functional group compatibility and the like. Because carbon dioxide is abundant, cheap and easily available and renewable C1 , The invention has great application value and social economic benefits.

Direct conversion of carboxylic acids to various nitrogen-containing compounds in the one-pot exploiting curtius rearrangement

Herein we report, a single-pot multistep conversion of inactivated carboxylic acids to various N-containing compounds using a common synthetic methodology. The developed methodology rendered the use of carboxylic acids as a direct surrogate of primary amines, for the synthesis of primary ureas, secondary/tertiary ureas, O/S-carbamates, benzoyl ureas, amides, and N-formyls, exploiting the Curtius reaction. This approach has a potential to provide a diversified library of N-containing compounds, starting from a single carboxylic acid, based on the selection of the nucleophile.

Method of N-formylating amines with a phosphonic anhydride

A method for N-formylating an amine that includes reacting the amine and a formamide compound in the presence of a phosphonic anhydride to form an N-formylated amine. The phosphonic anhydride is present in an amount of 5-100 mol % relative to a total number of moles of the amine, and the reacting is performed for 1-24 hours at a temperature of 45-100° C.

A process for preparing N - aryl amide compound

The method discloses a method used for preparing an N-aryl amide compound from amides and aniline compounds. According to the method, a palladium salt and a ligand are taken as catalysts; an N,N-dimethyl formamide compound, an aniline compound, a protonic acid, a Lewis acid, and an organic solvent are mixed; and an obtained mixture is subjected to heating reaction so as to obtain the N-aryl amide compound. Advantages of the method are that: preparation route is short, substrate universality is excellent, reaction conditions are mild, synthesis yield is high, and used raw materials and catalysts are simple and easily available.

Chemoselective Schwartz Reagent Mediated Reduction of Isocyanates to Formamides

Addition of the in situ generated Schwartz reagent to widely available isocyanates constitutes a chemoselective, high-yielding, and versatile approach to the synthesis of variously functionalized formamides. Steric and electronic factors or the presence of sensitive functionalities (esters, nitro groups, nitriles, alkenes) do not compromise the potential of the method. Full preservation of the stereochemical information contained in the starting materials is observed. The use of formamides in the nucleophilic addition of organometallic reagents (Chida-Sato allylation, Charette-Huang addition to imidoyl triflate activated amides, Matteson homologation of boronic esters) is briefly investigated.

Microwave-Assisted Formylations of Weakly Basic Anilines with Methyl Formate Catalyzed by Calcium and Hydrogen Triflimides

Catalytic amounts of calcium and hydrogen triflimides [Ca(NTf2)2, HNTf2] were found to be efficient for the solvent-free formylation of a variety of weakly basic anilines by using cheap and widely available methyl formate as the formylating agent under microwave irradiation. Initial investigations showed that in the case of calcium triflimide, Br?nsted acid catalysis was most likely operating. Remarkably, the corresponding calcium triflate and triflic acid were significantly less active.

Synthesis of N-arylcarboxamides by the efficient transamidation of DMF and derivatives with anilines

A novel protocol for the transamidation of DMF and derivatives with weakly nucleophilic anilines has been developed, utilizing a catalytic amount of Pd(OAc)2 and 2,2′-bipyridine, and with PivOH and BF3·Et2O as additives. This methodology has a broad substrate scope, and various corresponding transamidation products were prepared in good to excellent yields from commercially available DMF derivatives and anilines. The synthetic utility of the reported protocol was further demonstrated with a gram-scale experiment. Control experiments suggested the efficient transformation of DMF and derivatives with anilines might owe to the synergistic effect of palladium complex, PivOH, and BF3·Et2O.

ANTIVIRAL DRUGS FOR TREATMENT OF ARENA VIRUS INFECTION

Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by the Arenavirus family such as Lassa fever, Argentine hemorrhagic fever, Bolivian hemorrhagic fever, and Venezuelan hemorrhagic fever

A novel type of N-formylation and related reactions of amines via cyanides and esters as formylating agents

A novel N-formylation and related reactions proceed from cyanides promoted by esters. The Royal Society of Chemistry.