56355-62-5

Usage

Uses

Used in Pharmaceutical Industry:
METHYL (2-BROMO-5-METHYL-1,3-THIAZOL-4-YL)ACETATE is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of novel drug molecules. Its unique structure allows it to be a building block in creating therapeutic agents that address a range of health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, METHYL (2-BROMO-5-METHYL-1,3-THIAZOL-4-YL)ACETATE is utilized as an intermediate in the production of agrochemicals. Its incorporation aids in the development of compounds that can enhance crop protection, productivity, and overall agricultural sustainability.
Used in Organic Synthesis:
METHYL (2-BROMO-5-METHYL-1,3-THIAZOL-4-YL)ACETATE is also employed as an intermediate in organic synthesis for creating a variety of organic compounds. Its versatility in chemical reactions makes it a valuable component in the synthesis of specialty chemicals used in various applications, such as dyes, fragrances, and other industrial products.

Upstream product

• 72054-60-5 2-amino-5-methylthiazole-4-carboxylic acid ethyl ester 
• 57332-84-0 3-bromo-2-oxo-butyric acid ethyl ester 
• 15933-07-0 Ethyl 2-oxobutanoate 

Downstream Products

• 1204747-43-2 C₂₁H₁₇N₃O₂S 
• 1187836-86-7 (2-bromo-5-methyl-1,3-thiazol-4-yl)methanol 

Relevant academic research and scientific papers

Design and synthesis of novel triazole derivatives containing γ-lactam as potential antifungal agents

A series of novel triazole derivatives containing γ-lactam were designed and synthesized, and their structures were confirmed by 1H NMR, 13C NMR and HRMS. The in vitro antifungal activities of the target compounds were evaluated. The results showed that all of the compounds exhibited stronger activity against the six clinically important fungi tested than fluconazole. 3D and 3E showed comparative activity against the fungi tested except for Candida glabrata and Aspergillus fumigatus as voriconazole. In addition, the docking model for 2A and CYP51 was investigated.

IMIDAZOLE CARBONYL COMPOUND

To develop an antibiotic having a novel mechanism of action, the present inventors have searched for a compound that has weak cytotoxicity, the physical property of high solubility in water, the effect of inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and sufficient antibacterial activity. As a result, the present inventors have completed the present invention by finding that a compound of the present invention represented by the general formula (1), a pharmacologically acceptable salt thereof, and a prodrug thereof have desirable properties. The present invention provides a pharmaceutical composition (particularly, a preventive or therapeutic composition for infectious disease) comprising a compound represented by the formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof as an active ingredient.

HETEROCYCLYL-SUBSTITUTED ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS

This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts thereof, wherein R12 is a hydroxylated alkyl group and R9 contains a heterocyclic ring. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating atherosclerosis and preventing atherosclerotic disease events.

The Preparation of Thiazole-4- and -5-carboxylates, and an Infrared Study of their Rotational Isomers

Convenient general procedures have been developed for preparing series of thiazole-4- and -5-carboxylates containing alkyl and halogeno substituents.While both series of esters show i.r. carbonyl doublets caused by rotational isomerism, the more intense absorptions of the 4-carboxylates are the lower wavenumber components, whereas those of the 5-carboxylates are the higher wavenumber components.In both series the stronger bands arise from the thermochemically more stable forms; identification of these forms as the carbonyl O,S-syn-s-trans rotamers is more certain with the 4-carboxylates than with the 5-carboxylates.