56362-72-2Relevant academic research and scientific papers
Catalytic asymmetric hydroxylative dearomatization of 2-naphthols: Synthesis of lacinilene derivatives
Zhang, Yu,Liao, Yuting,Liu, Xiaohua,Xu, Xi,Lin, Lili,Feng, Xiaoming
, p. 6645 - 6649 (2017/08/29)
An enantioselective hydroxylative dearomatization of 2-naphthols with oxaziridines has been accomplished using a N,N′-dioxide-scandium(iii) complex catalyst. Various substituted ortho-quinols could be obtained in high yields (up to 99%) and enantioselectivities (up to 95:5 er). This methodology could be applied in the synthesis of bioactive lacinilenes in a gram-scale reaction. Based on the experimental investigations and previous work, a possible catalytic model was proposed.
