56405-37-9

Usage

Uses

Used in Biological Research:
2-METHYL-3-SULFOPROPYL BENZOTHIAZOLIUM INNER SALT is used as a staining agent for visualizing and tracking certain proteins and nucleic acids in cells and tissues. Its application is crucial for enhancing the visibility of these biomolecules under fluorescence microscopy and other imaging techniques, thereby aiding in the study of cellular processes and mechanisms.
Used in Imaging Techniques:
In the field of imaging, 2-METHYL-3-SULFOPROPYL BENZOTHIAZOLIUM INNER SALT is used as a fluorescent dye in techniques such as fluorescence microscopy and flow cytometry. Its fluorescent characteristics allow for the precise detection and quantification of target molecules, which is essential for research in cell biology, molecular biology, and related disciplines.
Used in Medical Diagnostics:
2-METHYL-3-SULFOPROPYL BENZOTHIAZOLIUM INNER SALT is used as a diagnostic tool in medical applications, capitalizing on its fluorescent properties to detect and monitor diseases at the molecular level. This can improve the accuracy and sensitivity of diagnostic tests, contributing to better patient outcomes.
Used in Environmental Monitoring:
In environmental science, 2-METHYL-3-SULFOPROPYL BENZOTHIAZOLIUM INNER SALT is used for monitoring and detecting contaminants or biological entities in various samples. Its ability to fluoresce under specific conditions makes it a valuable asset in tracking pollutants or assessing ecosystem health.
Used in Materials Science:
2-METHYL-3-SULFOPROPYL BENZOTHIAZOLIUM INNER SALT is utilized in materials science for developing new materials with unique optical properties. Its incorporation into materials can lead to advances in areas such as sensors, optoelectronics, and photonics, where fluorescent materials are of interest.

InChI:InChI=1/C11H13NO3S2/c1-9-12(7-4-8-17(13,14)15)10-5-2-3-6-11(10)16-9/h2-3,5-6H,4,7-8H2,1H3

Upstream product

• 1120-71-4 1,3-propanesultone 
• 120-75-2 2-Methylbenzothiazole 

Downstream Products

• 150196-53-5 2-{2-[4-(4,7,10,13-tetraoxa-1-azacyclopentadecyl)phenyl]ethenyl}-3-(3-sulphopropyl)benzothiazolium betaine 
• 150196-53-5 2-{2-[4-(4,7,10,13-tetraoxa-1-azacyclopentadecyl)phenyl]ethenyl}-3-(3-sulphopropyl)benzothiazolium betaine 
• 1208863-28-8 3-(4-nitrophenyl)-1-(3-propyl-2,3-dihydrobenzothiazol-2-ylidene)-5-[3-(3-sulfonatopropyl)benzothiazol-2-yl]pentamethinium 

Relevant academic research and scientific papers

A Reversible Photoacid Functioning in PBS Buffer under Visible Light

A metastable-state photoacid that can reversibly release a proton in PBS buffer (pH = 7.4) under visible light is reported. The design is based on the dual acid-base property and tautomerization of indazole. The quantum yield was as high as 0.73, and moderate light intensity (102 μmol·m2·s-1) is sufficient for the photoreaction. Reversible pH change of 1.7 units was demonstrated using a 0.1 mM aqueous solution. This type of photoacid is promising for control of proton-transfer processes in physiological conditions and may find applications in biomedical areas.

Accumulation of the photonic energy of the deep-red part of the terrestrial sun irradiation by rare-earth metal-free: E - Z photoisomerization

Large scale solar energy storage in the form of E-Z photoisomerisable organic materials requires avoidance of applying rare earth metals at any stage of the process used. Here, drastic shortening of the synthetic route of crown ether functionalized hemicyanine dyes, suitable for efficient E-Z photoisomerization under extremely low excitation light intensities compared with unconcentrated sunlight is reported. The higher energetic form was successfully stabilized by rare earth free cations-in this case by styryl dye-Ba2+ complexes. For the first time E-Z photoisomerization was demonstrated and was observed directly by excitation with light substantially red-shifted compared to the absorption spectrum of the trans-to-cis active moieties via the process of triplet-triplet annihilation upconversion.

Near-infrared double-acid dye connected with oxygen ether chain as well as preparation method and application thereof

The invention discloses a near-infrared double-acid dye connected with an oxygen ether chain, and preparation and application thereof. The 2 -methylbenzothiazole derivative and dicyanovinyl modified semiaromatic acid derivative which is linked with an oxygen ether chain is prepared from a raw material. The near-infrared both-side acid dye has good stability and excellent optical performance, and especially the introduction of a sulfonic acid group and an oxygen ether chain can enhance the water solubility of the dye. When the near-infrared double-acid dye is used for detection G - quadruplex, G - quadruplex can interact with the dye molecules, and the change of the dye absorption spectrum and the fluorescence spectrum is caused while G - quadruplex topological structure changes, so that the dye can be used as G - quadruplex. Fluorescent probes for detection.

4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof

The invention relates to a family of compounds that comprise fluorescent cyanine dyes. The compounds are near infrared absorbing heptamethine cyanine dyes with a 4,4-disubstituted cyclohexyl ring as part of the polymethine chromophore. The compounds are generally hydrophilic and can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications.

An activatable probe for detecting alcoholic liver injuryviamultispectral optoacoustic tomography and fluorescence imaging

A probe has been developed for imaging alcoholic liver injury through detecting the overexpressed cytochrome P450 reductase in hypoxia in the hepatic region. Upon response to the enzyme, the activated probe displays turn-on fluorescence and near-infrared absorption and generates prominent optoacoustic signals.

Simultaneous imaging of lysosomal and mitochondrial viscosity during mitophagy using molecular rotors with dual-color emission

Two molecular rotors with a single excitation and dual-color emission wavelengths were engineered for simultaneous imaging of lysosomal and mitochondrial viscosity. These two molecular rotors were highly sensitive to viscosity without dependence on pH or polarity, facilitating simultaneous imaging of lysosomal and mitochondrial viscosity during mitophagy in living cells.

Precious metal-free molecular machines for solar thermal energy storage

Four benzothiazolium crown ether-containing styryl dyes were prepared through an optimized synthetic procedure. Two of the dyes (4b and 4d) having substituents in the 5-position of the benzothiazole ring are newly synthesized compounds. They demonstrated a higher degree of trans-cis photoisomerization and a longer life time of the higher energy forms in comparison with the known analogs. The chemical structures of all dyes in the series were characterized by NMR, UV-vis, IR spectroscopy and elemental analysis. The steady-state photophysical properties of the dyes were elucidated. The stability constants of metal complexes were determined and are in good agreement with the literature data for reference dyes. The temporal evolution of trans-to-cis isomerization was observed in a real-time regime. The dyes demonstrated a low intrinsic fluorescence of their Ba2+ complexes and high yield of E/Z photoisomerization with lifetimes of the higher energy form longer than 500 seconds. Density functional theory (DFT) calculations at the B3LYP/6-31+G(d,p) level were performed in order to predict the enthalpies (H) of the cis and trans isomers and the storage energies (ΔH) for the systems studied.

Asymmetric anthocyanin dye and application thereof

The invention provides a compound adopting an asymmetric anthocyanin dye structure. The compound has a general chemical structure formula (I). The compound has no fluorescence itself, but can produceintensive fluorescence signals when composited with RNA, has the intensity of the fluorescence signal directly proportional to the concentration of RNA and has high selectivity for RNA. Therefore, theconcentration of RNA in biological samples can be simply and quickly determined by use of the compound.

Unsymmetrical cyanine dyes and their application

The invention describes the preparation and use of fluorescent stains for nucleic acids derived from unsymmetrical cyanine dyes. The dyes of the invention possess superior fluorescent properties when complexed with nucleic acids, and have utility in any application which requires detection of nucleic acids, such as detection of nucleic acids in solution, in gels, in blots, in microarrays, and in bacteria and cells, and for use in analysis of cell structure, membrane integrity, and function. The dyes of the invention have the formula where X is O, S, or C(CH3)2; Each of R1 and R6 is independently hydrogen, carboxy, sulfo, sulfonamide, halogen, CN, or alkoxy; Each of t and s is an integer from 0 to 4; R2 is an alkyl, or alkyl group substituted by a carboxy, or a sulfo; R3 is H, C6H4CO2R7, or C6H4CH2N(R7)2, where R7 is an alkyl; R4 is H, alkyl, aryl, halogen, alkoxy, alkylamino, or alkylthio; R5 is an alkyl, aryl, alkyl group substituted by a carboxy, or a sulfo, or —(CH2)a—[O—(CH2)b]m—O—Z, where Z is H, alkyl, or carboxy; each of a and b is an integer from 1 to 4; m is an integer selected from 0 to 4.

MODIFIED CARBOCYANINE DYES AND THEIR CONJUGATES

Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.