56410-31-2

Upstream product

• 31581-32-5 ethyl 2,4-dihydroxy-3,6-dimethylbenzoate 
• 100-44-7 benzyl chloride 

Downstream Products

• 56410-32-3 4-benzyloxy-2-hydroxy-3,6-dimethylbenzoic acid 
• 111258-40-3 methyl 4-O-benzyl-2,2'-di-O-methyleriodermate 
• 111258-38-9 methyl 4-O-benzyl-2-O-methyleriodermate 
• 111258-49-2 ethyl 4-benzyloxy-3-chloro-6-methoxy-2,5-dimethylbenzoate 
• 111258-50-5 4-benzyloxy-3-chloro-6-methoxy-2,5-dimethylbenzoic acid 
• 261174-81-6 C₃₀H₃₄O₇ 
• 261174-62-3 n-butyl 4-(4-benzyloxy-2-hydroxy-3,6-dimethylbenzoyloxy)-2-hydroxy-3,6-dimethylbenzoate 
• 261174-79-2 C₂₉H₃₂O₇ 
• 261174-60-1 n-propyl 4-(4-benzyloxy-2-hydroxy-3,6-dimethylbenzoyloxy)-2-hydroxy-3,6-dimethylbenzoate 
• 261174-61-2 i-propyl 4-(4-benzyloxy-2-hydroxy-3,6-dimethylbenzoyloxy)-2-hydroxy-3,6-dimethylbenzoate 
• 261174-59-8 ethyl 4-(4-benzyloxy-2-hydroxy-3,6-dimethylbenzoyloxy)-2-hydroxy-3,6-dimethylbenzoate 
• 261174-78-1 C₂₈H₃₀O₇ 
• 261174-80-5 C₂₉H₃₂O₇ 
• 261174-77-0 C₂₇H₂₈O₇ 

Relevant academic research and scientific papers

Depsides as non-redox inhibitors of leukotriene B4 biosynthesis and HaCaT cell growth. 1. Novel analogues of barbatic and diffractaic acid

A series of barbatic and diffractaic acid analogues has been synthesized and evaluated as inhibitors of leukotriene B4 (LTB4) biosynthesis and as antiproliferative agents. The 4-O-demethyl barbatic and diffractaic acid derivatives were among the most active compounds in both assays. In particular, ethyl 4-O-demethylbarbatate was the most potent LTB4 biosynthesis inhibitor of this series, with an IC50 value in the submicromolar range. Because the compounds did not show appreciable reactivity against a stable free radical, 2,2-diphenyl-1-picrylhydrazyl, and did not produce appreciable amounts of deoxyribose degradation as a measure of their potency to generate hydroxyl radicals, a simple redox effect could not explain their biological activity. Also, there was no nonspecific cytotoxicity as documented by the activity of lactate dehydrogenase released from the cytoplasm of keratinocytes, which was in the control range.