56414-65-4

Upstream product

• 123-75-1 pyrrolidine 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 1532548-78-9 1-(prop-2-ene-1-sulfinyl)pyrrolidine 
• 16707-70-3 2-(((benzyloxy)carbonyl)amino)ethanethioic S-acid 

Downstream Products

• 1355611-34-5 (E)-benzyl 5-phenyl-1-(pyrrolidin-1-yl)-1-thioxopent-4-en-2-ylcarbamate 
• 1236108-94-3 benzyl 3,3-dimethyl-1-(pyrrolidin-1-yl)-1-thioxopent-4-en-2-ylcarbamate 
• 1236108-91-0 benzyl (2-pyrrolidin-1-yl)-2-thioxoethylcarbamate 
• 82706-72-7 (2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pent-4-enoic acid 
• 912363-58-7 1-(2-benzyloxycarbonylamino-4-methyl-1-oxo-4-pentenyl)-pyrrolidine 
• 912363-52-1 1-(2-benzyloxycarbonylamino-3,3-dimethyl-1-oxo-4-pentenyl)-pyrrolidine 

Relevant academic research and scientific papers

Amides in one pot from Carboxylic Acids and Amines via Sulfinylamides

An efficient method has been developed for the direct amidification of carboxylic acids via sulfinylamides preformed in situ by the reaction of pure amines with prop-2- ene-1-sulfinyl chloride. The method can be applied to aliphatic acids, including pivalic acid, aromatic acids, and primary and secondary amines. It is compatible with acids bearing unprotected alcohol, phenol, and ketone moieties and applicable to the synthesis of peptides. It does not induce their a-epimerization.

Facile amide formation via S -nitrosothioacids

Here we report a novel amide bond formation strategy from simple thioacid and amine starting materials. The reaction is mediated by unstable but very reactive S-nitrosothioacid intermediates. This fast reaction under mild conditions should be useful in synthesis.(Figure Presented)

PEPTIDE DEFORMYLASE INHIBITORS

The present invention is directed to certain {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives, compositions containing them, the use of such compounds in the inhibition of bacterial peptide deformylase (PDF) activity, and in the treatment of bacterial infections. Specifically, the invention is directed to compounds of formula (I), wherein R1, R2 and R3 are defined herein and to pharmaceutically acceptable salts thereof. The compounds of this invention are bacterial peptide deformylase inhibitors and can be useful in the treatment of bacterial infections.

Synthesis of anti-β-substituted γ,δ-unsaturated amino acids via Eschenmoser-Claisen rearrangement

(Chemical Equation Presented) Anti-β-substituted γ,δ- unsaturated amino acids have been synthesized via a novel design of the Eschenmoser-Claisen rearrangement. The rearrangement gives good isolated yields and excellent diastereoselectivity due to (Z)-N,O-ketene acetal formation and the pseudochairlike conformations of the reaction intermediates. Upon reductive hydrolysis, important novel amino acids and amino alcohols were synthesized for the first time via this methodology.