56424-74-9Relevant academic research and scientific papers
Combating endoparasites with 3-hydroxybenzothiophenes
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, (2008/06/13)
A method of combating endoparasites in humans and animals which comprises administering to such humans and animals an endoparasiticidally effective amount of a 3-hydroxybenzothiophene of the formula STR1 in which X represents CH-- or N--,Y represents O or NH,R 1 represents one or more identical or different radicals from the group consisting of hydrogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, alkylenedioxy, halogenoalkylenedioxy, halogen, CN, NO 2, NH 2, alkylamino, dialkylamino, alkylcarbonyl, carbalkoxy, alkylsulphonyl, arylsulphonyl, sulphamoyl, alkylsulphamoyl, dialkylsulphamoyl, aryl, aryloxy and arylthio, which, in turn, may again be substituted,R 2 represents optionally substituted alkoxy, cycloalkoxy or the radical --NR 3 R 4,R 3 represents hydrogen or alkyl,R 4 represents an alkyl or carbocyclic or heterocyclic armoatic radical or the radical --COOR 5,R 3 and R 4, together with the adjacent nitrogen atom, represent a 5- or 6-membered heterocycle which may contain O or N as further heteroatoms and is optionally substituted by C 1 -C 4 -alkyl, C 1 -C 4 -hydroxyalkyl, C 1 -C 4 -halogenoalkyl or C 1 -C 4 -alkoxyalkylR 5 represents alkyl, cycloalkyl, aralkyl or aryl, which, in turn, may again be substituted or optionally substituted aryl.Many of the compounds are new, as well as their own intermediates.
Activities of 2-carboxanilido 3-hydroxybenzo[b]thiophens against molluscs Biomphalaria
Gayral,Buisson,Royer
, p. 187 - 189 (2007/10/02)
The title compounds are shown to be nearly as active against molluscs as Niclosamide when they are either dihalogenated or monohalogenated and mononitrated on the benzene ring.
