2527-63-1

Basic information

• Product Name: N,N'-Dithiobis(N-phenylbenzamide)
• Synonyms: N,N'-Dithiobis(N-phenylbenzamide)
• CAS NO: 2527-63-1
• Molecular Formula: C₂₆H₂₀N₂O₂S₂
• Molecular Weight: 456.5792
• Mol File: 2527-63-1.mol
• Article Data: 15

Chemical Properties

• Melting Point: 243 °C
• Boiling Point: 511.4°Cat760mmHg
• Flash Point: 263.1°C
• Appearance: /
• Density: 1.35g/cm³
• PKA: 12.71±0.70(Predicted)
• CAS DataBase Reference: N,N'-Dithiobis(N-phenylbenzamide)(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-Dithiobis(N-phenylbenzamide)(2527-63-1)
• EPA Substance Registry System: N,N'-Dithiobis(N-phenylbenzamide)(2527-63-1)

Safety Data

• Hazardous Substances Data: 2527-63-1(Hazardous Substances Data)

Upstream product

• 1677-27-6 3H-1,2-benzodithiol-3-one 
• 62-53-3 aniline 
• 77586-83-5 2-trichloromethyl-3,1-benzoxathian-4-one 
• 19602-82-5 2,2'-dithiodibenzoic acid dichloride 
• 342631-38-3 (E)-2-[2-(3-Chlorophenyl)vinyl]-3,1-benzoxathiin-4-one 
• 93-98-1 N-phenyl benzoyl amide 
• 6833-21-2 2-methoxy-N-phenylbenzamide 
• 18205-99-7 2-mercapto-N-phenylbenzamide 
• 147-93-3 Thiosalicylic acid 
• 119-80-2 2,2'-dithiobenzoic acid 

Downstream Products

• 18205-99-7 2-mercapto-N-phenylbenzamide 
• 855932-82-0 (2-phenylcarbamoyl-phenylsulfanyl)-acetic acid 
• 24434-82-0 benzo[b]thiophen-3-yl acetate 
• 2527-03-9 2-phenyl-1,2-benzisothiazolin-3-one 
• 93-98-1 N-phenyl benzoyl amide 
• 115484-13-4 2,2-thiobis(N-phenylbenzamide) 
• 1677-26-5 S-2-(phenylcarbamoyl)phenyl benzothioate 
• 10128-95-7 3-phenyl-benzo[e][1,3]thiazine-2,4-dithione 
• 7077-19-2 3-phenyl-4-thioxo-3,4-dihydro-benzo[e][1,3]thiazin-2-one 
• 7077-20-5 3-phenyl-2-thioxo-2,3-dihydrobenzo[e][1,3]thiazine-4-one 
• 20054-73-3 3-phenyl-benzo[e][1,3]thiazine-2,4-dione 
• 20051-28-9 3-phenyl-2-phenylimino-2,3-dihydro-benzo[e][1,3]thiazine-4-thione 
• 20054-79-9 S-Ethoxycarbonyl-N-phenyl-2-mercapto-benzamid 
• 20051-26-7 S-Methoxycarbonyl-dithio-salicylsaeureanilid ( S-Acetoxy-dithiosalicylsaeureanilid) 

Relevant articles and documents

Synthetic method 1-2 - benzisothiazol -3 -one compound (by machine translation)

The invention discloses a synthetic method of 1-2 - benzisothiazol -3 -one compound, and belongs to the field of chemical synthesis. 2 - 1-benzisothiazol 2 -one compounds are synthesized through acid chlorination, amidation and cyclization reaction by using the sulfenyl-substituted benzoic acid extracted from BIT process -3 - waste water as a starting raw material. The method disclosed by the invention has the advantages of mild reaction conditions, simple and convenient operation, strong practicability, less waste water, high product purity and the like, and is suitable for large-scale industrial production. The technical scheme provided by the invention is resource utilization and preparation 1 of wastewater extract produced in BIT production, and a feasible method is provided for the 2 -benzisothiazol -3 -one compound. (by machine translation)

Electron paramagnetic resonance spectroscopy as a probe of hydrogen bonding in heme-Thiolate proteins

Despite utilizing a common cofactor binding motif, hemoproteins bearing a cysteine-derived thiolate ligand (heme-Thiolate proteins) are involved in a diverse array of biological processes ranging from drug metabolism to transcriptional regulation. Though the origin of heme-Thiolate functional divergence is not well understood, growing evidence suggests that the hydrogen bonding (H-bonding) environment surrounding the Fe-coordinating thiolate influences protein function. Outside of X-ray crystallography, few methods exist to characterize these critical H-bonding interactions. Electron paramagnetic resonance (EPR) spectra of heme-Thiolate proteins bearing a six-coordinate, Fe(III) heme exhibit uniquely narrow low-spin (S = 1/2), rhombic signals, which are sensitive to changes in the heme-Thiolate H-bonding environment. To establish a well-defined relationship between the magnitude of g-value dispersion in this unique EPR signal and the strength of the heme-Thiolate H-bonding environment, we synthesized and characterized of a series of six-coordinate, aryl-Thiolate-ligated Fe(III) porphyrin complexes bearing a tunable intramolecular H-bond. Spectroscopic investigation of these complexes revealed a direct correlation between H-bond strength and g-value dispersion in the rhombic EPR signal. Using density functional theory (DFT), we elucidated the electronic origins of the narrow, rhombic EPR signal in heme-Thiolates, which arises from an Fe-S pI-dI bonding interaction. Computational analysis of the intramolecularly H-bonded heme-Thiolate models revealed that H-bond donation to the coordinating thiolate reduces thiolate donor strength and weakens this Fe-S interaction, giving rise to larger g-value dispersion. By defining the relationship between heme-Thiolate electronic structure and rhombic EPR signal, it is possible to compare thiolate donor strengths among heme-Thiolate proteins through analysis of low-spin, Fe(III) EPR spectra. Thus, this study establishes EPR spectroscopy as a valuable tool for exploring how second coordination sphere effects influence heme-Thiolate protein function.

REDOX DEHYDRATION COUPLING CATALYSTS AND METHODS RELATED THERETO

This disclosure relates to synthetic coupling methods using catalytic molecules. In certain embodiments, the catalytic molecules comprise heterocyclic thiolamide, S-acylthiosalicylamide, disulfide, selenium containing heterocycle, diselenide compound, ditelluride compound or tellurium containing heterocycle. Catalytic molecules disclosed herein are useful as catalysts in the transformation of hydroxy group containing compounds to amides, esters, ketones, and other carbon to heteroatom or carbon to carbon transformations.