56427-63-5Relevant academic research and scientific papers
Synthesis of benzothiophenones and naphthothiophenone as anticholinesterases
Jung
, p. 5325 - 5327 (2013/07/26)
Since AChE and BuChE belong to the same serine hydrolazes, we designed and synthesized compounds 1-6 as anticholinesterases and measured their inhibition poteucies on ChEs. 7-Methoxy-3H-benzo[c]thiophen-1-one 4, 4,6-dibromo-5,7- methoxy-3H-benzo[c]thiophe
ISOINDOLINE COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES
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Page/Page column 69-70, (2009/05/29)
Disclosed is a compound of Formula (I) in which W and R1-R6 are defined herein. Also disclosed is a method of treating spinal muscular atrophy, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the expression of a nucleic acid that encodes a translational stop codon introduced directly or indirectly by mutation or frameshift.
ISOINDOLONES WITH HIGH BINDING AFFINITY TO BETA-AMYLOID AGGREGATES AND FIBRILS, AND ITS USE AND PREPARATION METHOD
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Page/Page column 25-26, (2009/05/30)
The present invention relates to isoindolone compounds having high binding affinity to beta-amyloid fibrils, thereby being useful for an early diagnosis of degenerative cerebral diseases including dementia, and prevention and treatment of such diseases, i
[18F]-labeled isoindol-1-one and isoindol-1,3-dione derivatives as potential PET imaging agents for detection of β-amyloid fibrils
Lee, Ji Hoon,Byeon, Seong Rim,Kim, YoungSoo,Lim, Soo Jeong,Oh, Seung Jun,Moon, Dae Hyuk,Yoo, Kyung Ho,Chung, Bong Young,Kim, Dong Jin
scheme or table, p. 5701 - 5704 (2009/07/18)
In this study a novel series of isoindol-1-one and isoindol-1,3-dione derivatives for β-amyloid-specific binding agents is described. Twelve compounds were synthesized and evaluated via a competitive binding assay with [125I]TZDM against β-amyl
Ferroelectric liquid crystals induced by dopants with axially chiral 2,2′-spirobiindan-1,1′-dione cores
Boulton, Christopher J.,Finden, Jeremy G.,Yuh, Eagranie,Sutherland, Jeffrey J.,Wand, Michael D.,Wu, Gang,Lemieux, Robert P.
, p. 13656 - 13665 (2007/10/03)
The axially chiral dopants (R)-5,5′-, 5,6′-, and 6,6′-diheptyloxy-2,2′-spirobiindan-1,1′-dione ((R)-2, -3, and -4) were synthesized in optically pure form, and their absolute configurations were assigned by the exciton chirality method using circular dich
6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives
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, (2008/06/13)
6,11-Dihydrodibenz[b,e]oxepin-acetic acids and derivatives having the general formula STR1 are prepared by multi-step sequences. X is C=O, CHCl, CHBr, CH2 or CHOR4 ; Y is alkyl or alkoxy of 1 to 4 carbon atoms, halogen or trifluoromethyl; n is 0, 1, 2 or 3; Z is COOR5, CH2 OR5, CONR25 or CONHOR5 ; and R1 -R5 are hydrogen or alkyl of 1 to 4 carbon atoms. These compounds and the physiologically tolerable salts thereof are useful as antiinflammatory and analgesic agents.
Method of treating dermal inflammations
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, (2008/06/13)
A method of treating dermal inflammation by topically administering to a patient an effective amount of a 6,11-dihydrodibenz[b,e]oxepinalkanoic acid, physiologically tolerable salt thereof, derivative thereof, or diacid precursor thereof is described.
