56427-62-4

Usage

Synthesis Reference(s)

Tetrahedron Letters, 31, p. 481, 1990 DOI: 10.1016/0040-4039(90)87013-P

Upstream product

• 67-56-1 methanol 
• 487-51-4 4-carbethoxy-3-methyl-2-cyclohexen-1-one 
• 64-17-5 ethanol 
• 6245-57-4 4-methoxy-2-methylbenzoic acid 
• 201230-82-2 carbon monoxide 
• 27060-75-9 4-bromo-3-methylanisole 
• 58309-95-8 O-ethyl di(tert-butyl)phosphinite 

Downstream Products

• 56427-63-5 2-bromomethyl-4-methoxybenzoic acid ethyl ester 
• 55690-26-1 4-(2-carboxy-5-methoxybenzyloxy)phenylacetic acid 
• 867296-78-4 (RS)-2-ethoxycarbonyl-2-(2-(ethoxycarbonyl)-5-methoxybenzyl)-5-methoxy-1-indanone 
• 867296-82-0 (RS)-2-ethoxycarbonyl-2-(2-(ethoxycarbonyl)-5-methoxybenzyl)-6-methoxy-1-indanone 

Relevant academic research and scientific papers

Practical: In situ -generation of phosphinite ligands for palladium-catalyzed carbonylation of (hetero)aryl bromides forming esters

An effective method for alkoxycarbonylation of (hetero)aryl bromides is developed in the presence of in situ-generated phosphinite ligands tBu2POR (R = nBu, nPr, Et or Me). For this purpose commercially available tBu2PCl was used as the pre-ligand in the presence of different alcohols. For the first time cross coupling reactions with two alcohols-one generating the ligand, the other used as substrate-were developed. Through this method, ligand optimization can be performed in a more efficient manner and the desired products could be obtained with good yields and selectivity.

ISOINDOLINE COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES

Disclosed is a compound of Formula (I) in which W and R1-R6 are defined herein. Also disclosed is a method of treating spinal muscular atrophy, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the expression of a nucleic acid that encodes a translational stop codon introduced directly or indirectly by mutation or frameshift.

[18F]-labeled isoindol-1-one and isoindol-1,3-dione derivatives as potential PET imaging agents for detection of β-amyloid fibrils

In this study a novel series of isoindol-1-one and isoindol-1,3-dione derivatives for β-amyloid-specific binding agents is described. Twelve compounds were synthesized and evaluated via a competitive binding assay with [125I]TZDM against β-amyl

A Rapid Entry to Highly Functionalized p-Methoxybenzoates: Synthesis of Aromatic Portion of Milbemycin β3

A wide variety of easily accessable Hagemann's esters are converted to p-methoxybenzoates with iodine and methanol.