56434-28-7

Usage

Uses

Used in Pharmaceutical Synthesis:
6-Methoxypyridazine-3-carboxylic acid is used as a key intermediate in the synthesis of pyridazines and acetylpyridazines, which are important classes of compounds with a wide range of biological activities. These compounds have been found to possess various pharmacological properties, such as anti-inflammatory, anti-cancer, and anti-viral activities, making them valuable in the development of new drugs.
Used in Chemical Research:
In addition to its pharmaceutical applications, 6-Methoxypyridazine-3-carboxylic acid is also utilized as a reagent in chemical research. Its unique structure allows for further functionalization and modification, enabling the synthesis of a variety of novel compounds with potential applications in different fields, such as materials science, agrochemistry, and environmental science.

InChI:InChI=1/C6H6N2O3/c1-11-5-3-2-4(6(9)10)7-8-5/h2-3H,1H3,(H,9,10)

Upstream product

• 19194-96-8 methyl 6-methoxypyridazine-3-carboxylate 
• 5096-73-1 6-chloro-pyridazine-3-carboxylic acid 
• 124-41-4 sodium methylate 
• 65202-50-8 methyl 6-chloro-3-pyridazinecarboxylate 

Downstream Products

• 19194-96-8 methyl 6-methoxypyridazine-3-carboxylate 
• 98021-39-7 6-oxy-1,6-dihydropyridazine-3-carboxylic acid hydrazine 
• 63001-30-9 methyl 6‐oxo‐1,6‐dihydropyridazine‐3‐carboxylate 

Relevant academic research and scientific papers

PYRIDAZINE COMPOUND

The present provides a pyridazine compound having an inhibiting effect on Stearoyl-CoA desaturase (SCD) (in particular, SCD1). The present provides a compound represented by formula (where each symbol is as defined as in the Specification) or a salt thereof

6-methoxy diazine-3-carboxylic acid synthesis process

The present invention discloses a 6-methoxy diazine-3-carboxylic acid synthesis process, which comprises: 1) under ice bath, adding 3-chloro-6-methyl diazine to sulfuric acid, adding an oxidizing agent under stirring, carrying out a reaction at a temperature of 50-90 DEG C, cooling, adding ice water, diluting, extracting, combining the extraction liquid, drying, carrying out pressure reducing to achieve a dried state, and re-crystallizing the residue to obtain 6-chloro diazine-3-carboxylic acid; and 2) adding sodium methoxide and the 6-chloro diazine-3-carboxylic acid to the solvent in a stirring manner, carrying out a reflux reaction on the system, carrying out pressure reducing on the reaction liquid to remove the excess solvent, adding ice water, adjusting the pH value with concentrated hydrochloric acid, standing overnight, filtering, and re-crystallizing the filter cake by using water to obtain the 6-methoxy diazine-3-carboxylic acid. According to the present invention, the starting raw material is changed, is subjected to the domestic industrial production, and is easy to obtain, the synthetic steps are reduced, the operation process is reduced, and the 6-methoxy diazine-3-carboxylic acid synthesis is suitable for industrial production.

NEW COMPOUNDS

The present invention relates to new compounds of formula I, (I) a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.