564443-27-2

Usage

Uses

Used in Pharmaceutical Synthesis:
6-(trifluoromethyl)imidazo[2,1-b]thiazole-5-carbaldehyde is utilized as a key intermediate in the synthesis of pharmaceuticals due to its ability to contribute to the development of novel drug molecules. Its unique structure allows for the creation of compounds with potential therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, 6-(trifluoromethyl)imidazo[2,1-b]thiazole-5-carbaldehyde is employed as a precursor in the production of various agrochemicals. Its reactivity and functional groups facilitate the synthesis of compounds that can be used in crop protection and pest management.
Used in Dye and Pigment Manufacturing:
6-(trifluoromethyl)imidazo[2,1-b]thiazole-5-carbaldehyde is used as a building block in the manufacturing of dyes and pigments. Its chemical properties contribute to the creation of colorants with specific characteristics, such as stability and intensity, which are essential in various industries including textiles, plastics, and printing.
Used in Drug Discovery:
6-(trifluoromethyl)imidazo[2,1-b]thiazole-5-carbaldehyde serves as a valuable tool in drug discovery, where its unique structure and reactivity can be leveraged to design and develop new pharmaceutical agents. Its potential in this area is attributed to its ability to form diverse chemical entities with possible medicinal applications.
Used in Materials Science:
6-(trifluoromethyl)imidazo[2,1-b]thiazole-5-carbaldehyde is also utilized in materials science for the development of new materials with specific properties. Its incorporation into material compositions can lead to advancements in areas such as polymer science, nanotechnology, and material coatings.

InChI:InChI=1/C7H3F3N2OS/c8-7(9,10)5-4(3-13)12-1-2-14-6(12)11-5/h1-3H

Upstream product

• 109113-98-6 6-trifluoromethylimidazo<2,1-b>thiazole 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1007874-87-4 6-trifluoromethyl-imidazo[2,1-b]thiazole-5-carboxylic acid 
• 1257653-76-1 (E)-3-(6-(trifluoromethyl)imidazo[2,1-b]thiazol-5-yl)-1-(3,4-dimethoxyphenyl)prop-2-en-1-one 
• 1257653-74-9 (E)-3-(6-(trifluoromethyl)imidazo[2,1-b]thiazol-5-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 

Relevant academic research and scientific papers

Synthesis of imidazothiazole-chalcone derivatives as anticancer and apoptosis inducing agents

A new class of imidazo[2,1-b]thiazole chalcone derivatives were synthesized and evaluated for their anticancer activity. These chalcone derivatives show promising activity, with logGI50 values ranging from -7.51 to -4.00. The detailed biological aspects of these derivatives toward the MCF-7 cell line were studied. Interestingly, these chalcone derivatives induced G 0/G1-phase cell-cycle arrest, down-regulation of G 1-phase cell-cycle regulatory proteins such as cyclin D1 and cyclin E1, and up-regulation of CDK4. Moreover, these compounds elicit the characteristic features of apoptosis such as enhancement in the levels of p53, p21, and p27, suppression of NF-κB, and up-regulation of caspase-9. One of these chalcone derivatives, 3d, is potentially well suited for detailed biological studies, either alone or in combination with existing therapies. Breaking the cycle: We undertook an extensive examination of the ability of a series of new chalcone derivatives to regulate the cell cycle and to induce apoptosis in various cancer cell lines. Compound 3d is a particularly suitable candidate for further detailed biological investigations, especially in the treatment of breast cancer.

AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to novel azetidine compounds of formula (I), wherein R1, R2, and X are as described in the description and their use as orexin receptor antagonists.

TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES

The invention relates to novel trans-3-aza-bicyclo[3.1.0]hexane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

Imidazo[2,1-b]thiazole system: A scaffold endowing dihydropyridines with selective cardiodepressant activity

The synthesis, characterization, and functional in vitro assays in cardiac tissues and smooth muscle (vascular and nonvascular) of a number of 4-imidazo[2,1-b]thiazole-1,4-dihydropyridines are reported. The binding properties for the novel compounds have been investigated and the interaction with the binding site common to other aryl-dihydropyridines has been demonstrated. Interestingly, the novel 4-aryl-dihydropyridines are L-type calcium channel blockers with a peculiar pharmacological behavior. Indeed, the imidazo[2,1-b]thiazole system is found to confer to the dihydropyridine scaffold an inotropic and/or chronotropic cardiovascular activity with a high selectivity toward the nonvascular tissue. Finally, molecular modeling studies were undertaken for the most representative compounds with the aim of describing the binding properties of the new ligands at molecular level and to rationalize the found structure-activity relationship data. Due to the observed pharmacological behavior of our compounds, they might be promising agents for the treatment of specific cardiovascular pathologies such as cardiac hypertrophy and ischemia.

2-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES

The invention relates to novel 2-aza-bicyclo[3.1.0]hexane derivatives of Formula (I) wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.