56445-08-0 Usage
Uses
Used in Pharmaceutical Industry:
3-AMINO-N-ETHYLBENZENESULFONAMIDE is used as an intermediate in the synthesis of various pharmaceuticals for its antimicrobial and antifungal properties, contributing to the development of treatments for a range of infections.
Used in Agrochemical Industry:
In the agrochemical sector, 3-AMINO-N-ETHYLBENZENESULFONAMIDE serves as an intermediate in the production of agrochemicals, helping to create compounds that protect crops from microbial and fungal infections, thereby ensuring higher crop yields.
Used in Dye and Pigment Production:
3-AMINO-N-ETHYLBENZENESULFONAMIDE is utilized as a chemical intermediate in the manufacturing process of dyes and pigments, providing a foundation for the creation of a variety of colorants used in different industries.
Used as a Research Compound:
In research settings, 3-AMINO-N-ETHYLBENZENESULFONAMIDE is employed as a compound for studying its chemical properties and potential applications, including exploring its effectiveness as a pharmaceutical drug and its interactions with other chemical entities.
Check Digit Verification of cas no
The CAS Registry Mumber 56445-08-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,4,4 and 5 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 56445-08:
(7*5)+(6*6)+(5*4)+(4*4)+(3*5)+(2*0)+(1*8)=130
130 % 10 = 0
So 56445-08-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H12N2O2S/c1-2-10-13(11,12)8-5-3-4-7(9)6-8/h3-6,10H,2,9H2,1H3
56445-08-0Relevant articles and documents
Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors
Lawrence, Harshani R.,Kazi, Aslamuzzaman,Luo, Yunting,Kendig, Robert,Ge, Yiyu,Jain, Sanjula,Daniel, Kenyon,Santiago, Daniel,Guida, Wayne C.,Sebti, Said M.
experimental part, p. 5576 - 5592 (2010/09/15)
Screening of the NCI Diversity Set-1 identified PI-083 (NSC-45382) a proteasome inhibitor selective for cancer over normal cells. Focused libraries of novel compounds based on PI-083 chloronaphthoquinone and sulfonamide moieties were synthesized to gain a better understanding of the structure-activity relationship responsible for chymotrypsin-like proteasome inhibitory activity. This led to the demonstration that the chloronaphthoquinone and the sulfonamide moieties are critical for inhibitory activity. The pyridyl group in PI-083 can be replaced with other heterocyclic groups without significant loss of activity. Molecular modeling studies were also performed to explore the detailed interactions of PI-083 and its derivatives with the β5 and β6 subunits of the 20S proteasome. The refined model showed an H-bond interaction between the Asp-114 and the sulfonamide moiety of the PI-083 in the β6 subunit.
