28860-09-5 Usage
General Description
N-Ethyl 3-Nitrobenzenesulfonamide is a chemical compound that belongs to the class of sulfonamides and contains a nitro group and an ethyl substituent on the benzene ring. It is commonly used as a starting material in the synthesis of various pharmaceuticals and agrochemicals. N-ETHYL 3-NITROBENZENESULFONAMIDE has been identified as a potential intermediate in the production of dyes and pigments. It is also known for its use in the production of corrosion inhibitors and as a building block in the manufacturing of other chemical substances. Additionally, it has shown potential as an anti-inflammatory agent and has been studied for its potential use in the treatment of various diseases. However, its precise applications and uses are dependent on its specific properties and chemical reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 28860-09-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,8,6 and 0 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 28860-09:
(7*2)+(6*8)+(5*8)+(4*6)+(3*0)+(2*0)+(1*9)=135
135 % 10 = 5
So 28860-09-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N2O4S/c1-2-9-15(13,14)8-5-3-4-7(6-8)10(11)12/h3-6,9H,2H2,1H3
28860-09-5Relevant articles and documents
Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors
Lawrence, Harshani R.,Kazi, Aslamuzzaman,Luo, Yunting,Kendig, Robert,Ge, Yiyu,Jain, Sanjula,Daniel, Kenyon,Santiago, Daniel,Guida, Wayne C.,Sebti, Said M.
experimental part, p. 5576 - 5592 (2010/09/15)
Screening of the NCI Diversity Set-1 identified PI-083 (NSC-45382) a proteasome inhibitor selective for cancer over normal cells. Focused libraries of novel compounds based on PI-083 chloronaphthoquinone and sulfonamide moieties were synthesized to gain a better understanding of the structure-activity relationship responsible for chymotrypsin-like proteasome inhibitory activity. This led to the demonstration that the chloronaphthoquinone and the sulfonamide moieties are critical for inhibitory activity. The pyridyl group in PI-083 can be replaced with other heterocyclic groups without significant loss of activity. Molecular modeling studies were also performed to explore the detailed interactions of PI-083 and its derivatives with the β5 and β6 subunits of the 20S proteasome. The refined model showed an H-bond interaction between the Asp-114 and the sulfonamide moiety of the PI-083 in the β6 subunit.