56446-25-4Relevant articles and documents
Phthalazine PDE4 inhibitors. Part 3: The synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor
Napoletano, Mauro,Norcini, Gabriele,Pellacini, Franco,Marchini, Francesco,Morazzoni, Gabriele,Fattori, Raimondo,Ferlenga, Pierpaolo,Pradella, Lorenzo
, p. 5 - 8 (2007/10/03)
This communication describes the synthesis and in vitro evaluation of a novel and potent series of phthalazine phosphodiesterase type (IV) (PDE4) inhibitors. The interaction with two distinct polar binding sites allowed us to eliminate the cyclopentyloxy