564476-33-1 Usage
Uses
Used in Bioconjugation:
HS-PEG4-tBu is used as a bioconjugation agent for the formation of stable and soluble bioconjugates. The thiol group in HS-PEG4-tBu reacts with maleimide or other electrophilic groups present in biomolecules, such as proteins, peptides, and antibodies, enabling the formation of covalent bonds and the creation of bioconjugates with improved stability and solubility in aqueous media.
Used in Drug Delivery Systems:
In the pharmaceutical industry, HS-PEG4-tBu is used as a component in the design and synthesis of drug delivery systems. The hydrophilic PEG spacer and the reactive thiol group allow for the attachment of drug molecules to the PEG linker, improving the solubility, circulation time, and bioavailability of the drug in the body. Additionally, the t-butyl protected carboxyl group can be deprotected under acidic conditions, enabling the release of the drug in a controlled manner, such as in the acidic environment of tumor cells.
Used in Surface Modification:
HS-PEG4-tBu is used as a surface modification agent for various materials, including metals, polymers, and nanoparticles. The thiol group in HS-PEG4-tBu can form strong covalent bonds with transition metal surfaces, such as gold and silver, allowing for the functionalization and modification of these surfaces with PEG chains. This surface modification can improve the biocompatibility, stability, and resistance to protein adsorption of the modified surfaces, making them suitable for various applications, such as in biosensors, implants, and drug delivery systems.
Used in Hydrogel Formation:
In the field of tissue engineering and regenerative medicine, HS-PEG4-tBu is used as a crosslinking agent for the formation of hydrogels. The reactive thiol group can participate in Michael addition reactions with other thiol-reactive molecules, such as acrylate or vinyl sulfone groups, to form crosslinked hydrogels with tunable mechanical and swelling properties. These hydrogels can be used as scaffolds for cell culture, tissue engineering, and drug delivery applications.
Check Digit Verification of cas no
The CAS Registry Mumber 564476-33-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,6,4,4,7 and 6 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 564476-33:
(8*5)+(7*6)+(6*4)+(5*4)+(4*7)+(3*6)+(2*3)+(1*3)=181
181 % 10 = 1
So 564476-33-1 is a valid CAS Registry Number.
564476-33-1Relevant academic research and scientific papers
CYTOTOXIC AGENTS BEARING A REACTIVE POLYETHYLENE GLYCOL MOIETY, CYTOTOXIC CONJUGATES COMPRISING POLYETHYLENE GLYCOL LINKING GROUPS, AND METHODS OF MAKING AND USING THE SAME
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, (2008/06/13)
Cytotoxic agents bearing a polyethylene glycol (PEG) linking group having a terminal active ester, cytotoxic conjugates comprising one or more cytotoxic agents linked to a cell-binding agent via PEG linking groups, and methods for producing both are disclosed. A therapeutic composition comprising a therapeutically-effective amount of one of the cytotoxic conjugates of the present invention, and a method of killing selected cell populations comprising contacting target cells, or tissue containing target cells, with an effective amount of one of the cytotoxic conjugates, are also disclosed.
Synthesis of taxoids with improved cytotoxicity and solubility for use in tumor-specific delivery
Miller, Michael L.,Roller, Elizabeth E.,Zhao, Robert Y.,Leece, Barbara A.,Ab, Olga,Baloglu, Erkan,Goldmacher, Victor S.,Chari, Ravi V. J.
, p. 4802 - 4805 (2007/10/03)
To develop effective taxane-antibody immunoconjugates, we have prepared a series of modified taxanes that have both improved toxicity and solubility in aqueous systems as compared to paclitaxel (1a). These taxanes have been modified at either the C-10 or
Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use
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, (2008/06/13)
A cytotoxic agent comprising one or more polyethylene glycol-containing taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more polyethylene glycol-containing taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient. A method for killing selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more polyethylene glycol-containing taxanes linked to a cell binding agent.
