56453-96-4Relevant academic research and scientific papers
Synthesis of 5-chloropyrrole carboxaldehydes from 5-oxopyrrolidine carboxamides
Netchitailo, Pierre,Othman, Mohamed,Daich, Adam,Decroix, Bernard
, p. 3227 - 3230 (2007/10/03)
N-alkyl-5-chloropyrrole-2(or 3)-carboxaldehydes are obtained by treatment of N-alkyl-5-oxopyrrolidine-2 (or 3)-carboxamides by phosphorus oxychloride and basic hydrolysis.
Vilsmeier-Haack reaction with succinamidals. A convenient synthesis of 5-chloropyrrole-2-carboxaldehydes and 5-chloropyrrole-2,4-dicarboxaldehydes
Guzman, Angel,Romero, Moises,Muchowski, Joseph M.
, p. 791 - 794 (2007/10/02)
It is shown that the reaction of N-alkylsuccinamidals (2) with Vilsmeier-Haack reagent derived from DMF and phosphorus oxychloride can be controlled to preferentially produce either 5-chloropyrrole-2-carboxaldehydes (8) or 5-chloropyrrole-2,4-dicarboxalde
