41194-00-7

Usage

Uses

Used in Chemical Industry:
5-Hydroxy-1-methyl-2-pyrrolidone is used as a chemical intermediate for the synthesis of various compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique chemical structure allows it to be a versatile building block in the development of new molecules with potential applications in different fields.
Used in Pharmaceutical Industry:
As a metabolite of N-methylpyrrolidone, 5-Hydroxy-1-methyl-2-pyrrolidone may have potential applications in the pharmaceutical industry, particularly in the development of new drugs or drug delivery systems. Its chemical properties could be exploited to improve the solubility, stability, or bioavailability of active pharmaceutical ingredients.
Used in Research and Development:
5-Hydroxy-1-methyl-2-pyrrolidone can be utilized in research and development settings to study the metabolic pathways of N-methylpyrrolidone and its potential effects on human health and the environment. Understanding the properties and behavior of this metabolite can contribute to the development of safer and more sustainable industrial processes.
Used in Environmental Applications:
5-Hydroxy-1-methyl-2-pyrrolidone may have potential applications in environmental remediation, such as the treatment of wastewater or soil contaminated with N-methylpyrrolidone. Its chemical properties could be harnessed to facilitate the removal or degradation of the parent compound, thereby reducing its environmental impact.
Used in Material Science:
The unique chemical structure of 5-Hydroxy-1-methyl-2-pyrrolidone may also find applications in the field of material science, where it could be used to develop new polymers or other advanced materials with specific properties, such as improved mechanical strength, thermal stability, or chemical resistance.

Upstream product

• 872-50-4 1-methyl-pyrrolidin-2-one 
• 1121-07-9 N-methylsuccinimide 
• 930-88-1 N-methylmaleimide 

Downstream Products

• 1121-07-9 N-methylsuccinimide 
• 56453-96-4 5-Chlor-1-methyl-pyrrol-2-carboxaldehyd 
• 129461-26-3 5-chloro-1-methyl-2-formylpyrrol-4-carboxaldehyde 
• 54520-83-1 1-methyl-5-phenyl-2-pyrrolidinone 
• 122695-53-8 1-methyl-5-oxopyrrolidin-2-yl acetate 
• 1253522-98-3 1-benzyl-3-bromo-5-(1-methyl-5-oxopyrrolidin-2-yl)pyridin-1-ium trifluoromethanesulfonate 
• 60307-25-7 (1-methyl-5-oxo-pyrrolidin-2-yl)-acetic acid 

Relevant academic research and scientific papers

Construction of Functionalized Azapolycyclic Architectures via Formal Amide Insertion at a Low Catalyst Loading of Copper Trifluoroacetylacetonate

A formal amide insertion reaction for the synthesis of nitrogen-bridged polycyclic frameworks with diverse functionalities was developed using a sustainable copper catalyst as an advantageous alternative to precious rhodium catalysts. The remarkable feature of this methodology is the amount of catalyst loading (0.05 mol%). The optimized reaction conditions enable access to aromatic ring-fused 8-azabicyclo[3.2.1]octane, 9-azabicyclo[3.3.1]nonane, and 6-azabicyclo[3.2.2]nonane derivatives in moderate to excellent yields. (Figure presented.).

Iron-Promoted Reductive Ring-Opening and Isomerization Reactions of C4-Alkynylisoxazoles Leading to 2-Alkynylenaminones and Polysubstituted Furans

A new iron(III)-promoted reductive ring-opening and isomerization reactions of C4-alkynylisoxazoles in the oxidized N-methylpyrrolidone (NMP*) was reported. By changing the substituents at the C3 and C5 position of the isoxazole ring, the reaction selecti

One-pot synthesis of pyrrolidino- and piperidinoquinolinones by three-component aza-Diels-Alder reactions of in situ generated N-arylimines and cyclic enamides

An efficient synthesis of hexahydropyrrolo[3,2-c]quinolin-2-ones and hexahydropyridino[3,2-c]quinolin-2-ones has been developed in moderate to high yields by one-pot two-step aza-Diels-Alder reactions of N-arylimines, formed in situ from anilines and benz

One-pot formation of piperidine- and pyrrolidine-substituted pyridinium salts via addition of 5-alkylaminopenta-2,4-dienals to N-acyliminium ions: Application to the synthesis of (±)-nicotine and analogs

Addition of 5-alkylaminopenta-2,4-dienals onto N-acyliminium ions, generated in situ from α-hydroxycarbamates derived from pyrrolidine or piperidine, in the presence of zinc triflate, followed by dehydrative cyclization, allowed the formation of pyridinium salts substituted at their 3-position by a five- or six-membered nitrogen heterocycle. Subsequent N-dealkylation of the pyridinium moiety and deprotection of the secondary amine or reduction of the carbamate function led to (±)-nicotine and analogs.

The photooxidative degradation of N-methylpyrrolidinone in the presence of Cs3PW12O40 and TiO2 colloid photocatalysts

The mechanisms of the heterogeneous photocatalytic behavior of TiO2 and Cs3PW12O40 for the oxidative destruction of N-methylpyrrolidinone (NMP) in water are discussed. Both photocatalysts generate H-methylsuccinimide (NMS) and succinimide as the main intermediates from oxidation at the α-carbon and methyl positions. 2-Pyrrolidmone (2P) and 5-hydroxy-N-methylpyrrolidinone (5-HNMP) have also been identified as primary intermediates These intermediates are all broken down under further photooxidation. However, differences in product distribution indicate the possibility of several mechanistic pathways. Hydroxyl radical-like attack predominates for TiO2- photocatalyzed degradation, whereas the polyoxotungstate appears to oxidatrvely destroy NMP by both OH radical attack and direct oxidation For TiO2, the relative quantum yields for NMP oxidation (0.5 g L-1 TiO2, pH 3. 254 nm, 7 × 10-6 ein sec-1) increase from 3PW12O40 under the same conditions, the apparent quantum yield is nearly invariant (0.005-0.009) over the concentration range 10- 1000 ppm.

Ruthenium Tetroxide Oxidation of N-Alkyllactams

Ruthenium tetroxide (RuO4) oxidation of N-alkyllactams proceeded regioselectively depending on the size of lactam ring, except for the seven-membered ring.Four- and eight-membered N-methyl- and N-ethyllactams were oxidized at the exocyclic α-carbon adjacent to nitrogen to produce the N-acyllactams and NH-lactams, while five- and six-membered lactams underwent endocyclic oxidation to yield the cyclic imides.Oxidation of seven-membered lactams yielded a mixture of products arising from both exocyclic and endocyclic oxidations.These regioselectivities were confirmed in the oxidation of substrates having a tertiary carbon at the oxidation position.Keywords---oxidation; ruthenium tetroxide oxidation; regioselective oxidation; hydroxylation; imide synthesis; N-alkyllactam; N-acyllactams; imide; ruthenium tetroxide; two-phase method