56460-36-7 Usage
Uses
Used in Pharmaceutical Industry:
4-Hydroxy-3,5-diiodo-benzeneacetic Acid Methyl Ester is used as an intermediate in the synthesis of Thyroxine derivatives for the pharmaceutical industry. Its role in the production of these derivatives is essential due to its potential effect on maintaining metabolic homeostasis. Thyroxine is a hormone that plays a vital role in regulating the body's metabolism, and its derivatives can be used to treat various conditions related to metabolic imbalances.
Used in Metabolic Homeostasis Regulation:
4-Hydroxy-3,5-diiodo-benzeneacetic Acid Methyl Ester is used as a key component in the development of drugs that target the regulation of metabolic homeostasis. 4-Hydroxy-3,5-diiodo-benzeneacetic Acid Methyl Ester's unique structure allows it to be incorporated into Thyroxine derivatives, which can help maintain a balance in the body's metabolic processes. This application is particularly relevant for individuals suffering from conditions such as hypothyroidism, where the production of thyroid hormones is insufficient, leading to metabolic imbalances.
Check Digit Verification of cas no
The CAS Registry Mumber 56460-36-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,4,6 and 0 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 56460-36:
(7*5)+(6*6)+(5*4)+(4*6)+(3*0)+(2*3)+(1*6)=127
127 % 10 = 7
So 56460-36-7 is a valid CAS Registry Number.
56460-36-7Relevant academic research and scientific papers
Synthesis of MR-49, a deiodinated analog of tetraiodothyroacetic acid (tetrac), as a novel pro-angiogenesis modulator
Rajabi, Mehdi,Sudha, Thangirala,Darwish, Noureldien H.E.,Davis, Paul J.,Mousa, Shaker A.
supporting information, p. 4112 - 4116 (2016/08/01)
The tyrosine-based hormones 3,3′,5-triiodo-L-thyronine (L-T3) and L-thyroxine (L-T4) that are produced by the thyroid gland control metabolic functions. Iodothyronine deiodinase enzymes convert L-T4to L-T3, the form of thyroid hormone critical to genomic actions within cells and regulation of metabolism, and to reverse-L-T3, a hormone isoform that is largely inactive. We used tertiary amines in a study of deiodination based on derivatives of tetraiodothyroacetic acid (tetrac)—a naturally occurring derivative of L-T4—to mimic the action of the iodothyronine deiodinases and deiodination of the outer ring iodines. Deiodinated tetrac, MR-49, was found to be pro-angiogenic, with this activity exceeding that of L-T3and L-T4in a hemoglobin Matrigel plug assay of angiogenesis. Tetrac is anti-angiogenic via several nongenomic pathways, and the present studies of MR-49 reveal the critical contribution of outer ring iodines to the angiogenic properties of thyroid hormone analogues, which may have utility as pro-angiogenic pharmaceuticals.
