56461-06-4Relevant academic research and scientific papers
Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase
Tang, Jing,Vernekar, Sanjeev Kumar V.,Chen, Yue-Lei,Miller, Lena,Huber, Andrew D.,Myshakina, Nataliya,Sarafianos, Stefan G.,Parniak, Michael A.,Wang, Zhengqiang
, p. 85 - 96 (2017)
Human immunodeficiency virus (HIV) reverse transcriptase (RT) associated ribonuclease H (RNase H) remains the only virally encoded enzymatic function not clinically validated as an antiviral target. 2-Hydroxyisoquinoline-1,3-dione (HID) is known to confer
