56464-69-8

Upstream product

• 66985-49-7 2-(4-methylphenyl)-2-(trimethylsilyloxy)acetonitrile 
• 773837-37-9 sodium cyanide 
• 104-87-0 4-methyl-benzaldehyde 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 151-50-8 potassium cyanide 
• 143-33-9 sodium cyanide 
• 4815-10-5 2-hydroxy-2-(4-methylphenyl)acetonitrile 

Downstream Products

• 110087-90-6 N-acetylamino-1-(4-methylphenyl)acetonitrile 
• 13227-01-5 2-amino-2-(4-methylphenyl)acetic acid 
• 110087-94-0 N,N'diacetyl-1-(4-methylphenyl)ethylenediamine 
• 41175-78-4 1-(4-methylphenyl)ethylenediamine dihydrochloride 
• 109858-31-3 N,N'-(1-(4-methylphenyl)ethane-1,2-diyl)bis 
• 59133-31-2 3-Amino-4,5-dicarbomethoxy-2-(p-tolyl)pyrrole hydrochloride 
• 93554-84-8 DL-4-methylphenylglycine nitrile hydrochloride 
• 1265223-81-1 N-(cyano(p-tolyl)methyl)-2-nitrobenzamide 
• 56463-61-7 4-acetyl-3-amino-5-methyl-2-(p-tolyl)-pyrrole 
• 119615-71-3 (S)-2-amino-2-(p-tolyl)acetic acid 
• 25074-36-6 C₉H₇ClN₂ 

Relevant academic research and scientific papers

Titanium-Catalyzed Cyano-Borrowing Reaction for the Direct Amination of Cyanohydrins with Ammonia

α-Aminonitrile was an important building block in natural products and key intermedia in organic chemistry. Herein, the direct amination of cyanohydrins with the partner of ammonia to synthesis N-unprotected α-aminonitriles is developed. The reaction proceeds via titanium-catalyzed cyano-borrowing reaction, which features high atom economy and simple operation. A broad range of ketone or aldehyde cyanohydrins was tolerated with ammonia, and the N-unprotected α-aminonitriles were synthesis with moderate to high yields under mild reaction conditions.

Gold-catalyzed oxidative couplings of two indoles with one aryldiazo cyanide under oxidant-free conditions

Gold-catalyzed oxidative couplings of two indoles and one α-cyano gold carbene to form bis(indolyl)methane derivatives are described. Two different indoles are compatible with these reactions to provide reasonable yields. A plausible mechanism is postulated to rationalize the experimental data including product distributions, D2O labeling, and the significant effects of gold catalysts and cyano groups.

Gold-catalyzed [3+2]-annulations of α-aryl diazonitriles with ynamides and allenamides to yield 1-amino-1H-indenes

Gold-catalyzed [3+2]-annulations of α-aryl diazonitriles with ynamides and allenamides yield 1-amino-1H-indenes in two distinct pathways; the success of these annulations relies on the high electrophilicity of α-cyano arylgold carbenes to activate an ionic pathway.

SUBSTITUTED PHENYLLUREAS AND PHENYLAMIDES AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted phenylureas and phenylamides of formula (I), to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions.

Development of a new α-aminonitrile synthesis

α-Aminonitriles are prepared upon reaction of aryl carboxaldehydes with LiHMDS and acetone cyanohydrin. This new method provides a general route to the synthesis of various substituted α-aminoarylacetonitriles in high yield and purity, and avoids the use of the highly toxic cyanide salts.

Inhibitors of phenylalanine ammonialyase: 1-aminobenzylphosphonic acids substituted in the benzene ring

Dextrorotatory 1-amino-3′,4′-dichlorobenzylphosphonic acid was found to be a potent inhibitor of the plant enzyme phenylalanine ammonia-lyase both in vitro and in vivo from among the ring-substituted 1-aminobenzylphosphonic acids and other analogues of phenylglycine. A structure activity relationship analysis of the results obtained permits predictions on the geometry of the pocket of the enzyme and is a basis in the strategy of better inhibitor synthesis.

Highly efficient and enantioselective synthesis of L-arylglycines and D-arylglycine amides from biotransformations of nitriles

Under very mild conditions, the Rhodococcus sp. AJ270-catalysed biotransformation of arylglycine nitriles 1, prepared easily from the reaction of substituted benzaldehydes, ammonium chloride and potassium cyanide, proceeded efficiently to produce optically active D-arylglycine amides 2 and L-arylglycines 3 in excellent yields with enantiomeric excesses higher than 99%.

Triplet photochemistry of acyl and imino cyclopropenes. a rearrangement to afford furans and pyrroles: Reaction and mechanism

Syntheses of 3-substituted 3-acylcyclopropenes and 3-benzoylcyclopropene imines were devised. A triplet rearrangement of acylcyclopropenes having C-3 aryl substitution to afford furans has been uncovered and studied with several examples. Unlike the singl

Phenyl Tetraacetic Acid Ligands for Gadolinium: Potential Magnetic Resonance Image Enhancing Agents

Three new ligands suitable for chelation to gadolinium have been synthesized.N,N'->bis and N,N'->bis were prepa