56464-71-2

Upstream product

• 53313-96-5 α-hydroxy-3-methylbenzeneacetonitrile 
• 143-33-9 sodium cyanide 
• 620-23-5 m-tolyl aldehyde 

Downstream Products

• 56463-70-8 1-(4-amino-2-methyl-5-m-tolyl-pyrrol-3-yl)-ethanone 
• 1072449-62-7 C₉H₁₁NO₂*ClH 

Relevant academic research and scientific papers

Titanium-Catalyzed Cyano-Borrowing Reaction for the Direct Amination of Cyanohydrins with Ammonia

α-Aminonitrile was an important building block in natural products and key intermedia in organic chemistry. Herein, the direct amination of cyanohydrins with the partner of ammonia to synthesis N-unprotected α-aminonitriles is developed. The reaction proceeds via titanium-catalyzed cyano-borrowing reaction, which features high atom economy and simple operation. A broad range of ketone or aldehyde cyanohydrins was tolerated with ammonia, and the N-unprotected α-aminonitriles were synthesis with moderate to high yields under mild reaction conditions.

Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them and use thereof for treating pain and other conditions

Compounds corresponding to formula I: which act as vanilloid receptor ligands, pharmaceutical compositions containing such compounds, a process for the producing such compounds, and the use thereof to treat or inhibit pain and/or various other disorders or conditions.