56489-65-7Relevant academic research and scientific papers
GM3 analogue
-
, (2007/10/10)
PROBLEM TO BE SOLVED: To provide an oligomer of lyso GM3 or its analogue, which has an activity for inhibiting the phosphation of EGFR (epitheliocyte growth factor receptor) and is useful as an anticancer agent. ?SOLUTION: This compound is represented by the formula of Figure. The medicine contains the compound as an active ingredient. ?COPYRIGHT: (C)2008,JPOandINPIT ?
Cytostatic 6-arylpurine nucleosides IV. Synthesis of 2-substituted 6-phenylpurine ribonucleosides
Hocek, Michal,Holy, Antonin,Dvorakova, Hana
, p. 325 - 335 (2007/10/03)
A series of 2-X-substituted-6-phenyl-9-(β-D-ribofuranosyl)purines (X = Cl, Br, I, CH3, CF3 and Ph) was prepared by halo-deaminations of protected 2-amino-6-phenylpurine ribonucleoside, by regioselective Suzuki-Miyaura reactions of 2,
Synthetic Transformations of Transient Purinyl Radicals: Formation of Mono- and Diarylated and Heteroarylated Nucleosides
Nair, Vasu,Young, David A.
, p. 4340 - 4344 (2007/10/02)
Photolysis of 2,6-dihalogenated purine nucleosides produced, through cleavage of the carbon-halogen bond, both purin-2-yl and purin-6-yl radicals (or caged radical pairs) which were intercepted by aromatic solvents such as benzene to produce 2-aryl- or 2,6-diarylpurine nucleosides.Heteroarylations and their selectivities involving pyrrole, thiophene, furan, and pyridine systems were als explored.In all cases, except for the "?-deficient" pyridine, the photoinduced heteroarylations were regiospecific and the products photostable.Photoinduced hydration of 2-substituted 6-chloropurine nucleosides provides an excellent approach for the synthesis of uncommon 2-substituted inosine analogues.High-field 13C NMR data suggest that the 2,6-disubstituted purine nucleosides prefer the anti conformation in solution.
