71122-76-4Relevant academic research and scientific papers
Synthetic Transformations of Transient Purinyl Radicals: Formation of Mono- and Diarylated and Heteroarylated Nucleosides
Nair, Vasu,Young, David A.
, p. 4340 - 4344 (1984)
Photolysis of 2,6-dihalogenated purine nucleosides produced, through cleavage of the carbon-halogen bond, both purin-2-yl and purin-6-yl radicals (or caged radical pairs) which were intercepted by aromatic solvents such as benzene to produce 2-aryl- or 2,6-diarylpurine nucleosides.Heteroarylations and their selectivities involving pyrrole, thiophene, furan, and pyridine systems were als explored.In all cases, except for the "?-deficient" pyridine, the photoinduced heteroarylations were regiospecific and the products photostable.Photoinduced hydration of 2-substituted 6-chloropurine nucleosides provides an excellent approach for the synthesis of uncommon 2-substituted inosine analogues.High-field 13C NMR data suggest that the 2,6-disubstituted purine nucleosides prefer the anti conformation in solution.
Cytostatic 6-arylpurine nucleosides IV. Synthesis of 2-substituted 6-phenylpurine ribonucleosides
Hocek, Michal,Holy, Antonin,Dvorakova, Hana
, p. 325 - 335 (2007/10/03)
A series of 2-X-substituted-6-phenyl-9-(β-D-ribofuranosyl)purines (X = Cl, Br, I, CH3, CF3 and Ph) was prepared by halo-deaminations of protected 2-amino-6-phenylpurine ribonucleoside, by regioselective Suzuki-Miyaura reactions of 2,
