565-16-2

Basic information

• Product Name: ethyl 2-fluoro-3-hydroxy-3-phenylbutanoate
• Synonyms: ethyl 2-fluoro-3-hydroxy-3-phenylbutanoate
• CAS NO: 565-16-2
• Molecular Weight: 226.248
• Mol File: 565-16-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 2-fluoro-3-hydroxy-3-phenylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-fluoro-3-hydroxy-3-phenylbutanoate(565-16-2)
• EPA Substance Registry System: ethyl 2-fluoro-3-hydroxy-3-phenylbutanoate(565-16-2)

Safety Data

• Hazardous Substances Data: 565-16-2(Hazardous Substances Data)

Upstream product

• 401-55-8 ethyl bromofluoroacetate 
• 98-86-2 acetophenone 
• 92397-82-5 ((E)-1-Ethoxy-2-fluoro-vinyloxy)-trimethyl-silane 
• 83192-17-0 lithium enolate of ethyl fluoroacetate 

Relevant articles and documents

Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

The application of Reformatsky and Blaise reactions for the preparation of a diverse set of valuable intermediates and heterocycles in a one-pot protocol is described. To achieve this goal, a greener activation protocol for zinc in flow conditions has been developed to introduce this metal efficiently into α-bromoacetates. The organozinc compounds were added to a diverse set of ketones and nitriles to obtain a wide range of functional groups and heterocyclic systems.

Preparation of α-Fluoro Enolates and Their Use in the Directed Aldol Reaction

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