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Ethyl 2-fluoro-3-hydroxy-3-phenylbutanoate is a chemical compound with the molecular formula C12H15FO3. It is a derivative of a butanoic acid, featuring a fluorine atom at the 2nd carbon, a hydroxyl group at the 3rd carbon, and a phenyl group attached to the 3rd carbon as well. This organic molecule is an ester, formed by the reaction of the carboxylic acid group with ethanol. It is a colorless liquid with a specific molecular weight of 222.24 g/mol. Ethyl 2-fluoro-3-hydroxy-3-phenylbutanoate is used in the synthesis of various pharmaceuticals and agrochemicals due to its unique structure and reactivity. Its properties, such as the presence of a fluorine atom, can significantly influence its chemical behavior and potential applications in the fields of drug development and chemical research.

565-16-2

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565-16-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 565-16-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,6 and 5 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 565-16:
(5*5)+(4*6)+(3*5)+(2*1)+(1*6)=72
72 % 10 = 2
So 565-16-2 is a valid CAS Registry Number.

565-16-2Downstream Products

565-16-2Relevant academic research and scientific papers

Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

Huck,Berton,De La Hoz,Díaz-Ortiz,Alcázar

supporting information, p. 1420 - 1424 (2017/05/12)

The application of Reformatsky and Blaise reactions for the preparation of a diverse set of valuable intermediates and heterocycles in a one-pot protocol is described. To achieve this goal, a greener activation protocol for zinc in flow conditions has been developed to introduce this metal efficiently into α-bromoacetates. The organozinc compounds were added to a diverse set of ketones and nitriles to obtain a wide range of functional groups and heterocyclic systems.

Ethyl α-fluoro silyl enol ether: Stereoselective synthesis and its aldol reaction with aldehydes and ketones

Huang, Xiao-Ting,Chen, Qing-Yun

, p. 3231 - 3234 (2007/10/03)

Ethyl α-fluoro silyl enol ether is stereoselectively synthesized in high yield from inexpensive chlorofluoroacetate and Mg (or Zn) in DMF (or HMPA). Lewis acid promoted aldol reaction of this enol ether with aldehydes and ketones gives α-fluoro-β-hydroxy

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