56504-52-0

Basic information

• Product Name: 4,5-Dichloro-3-piperidinoylisothiazole
• Synonyms: 4,5-Dichloro-3-piperidinoylisothiazole;4,6-dihydroxy-5-(3-methoxybenzylidene)-2(5H)-pyrimidinone
• CAS NO: 56504-52-0
• Molecular Formula: C₁₂H₁₀N₂O₄
• Molecular Weight: 246.22
• Mol File: 56504-52-0.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,5-Dichloro-3-piperidinoylisothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Dichloro-3-piperidinoylisothiazole(56504-52-0)
• EPA Substance Registry System: 4,5-Dichloro-3-piperidinoylisothiazole(56504-52-0)

Safety Data

• Hazardous Substances Data: 56504-52-0(Hazardous Substances Data)

Upstream product

• 873-83-6 4-Amino-2,6-dihydroxypyrimidine 
• 591-31-1 3-methoxy-benzaldehyde 
• 67-52-7 BARBITURIC ACID 

Downstream Products

• 152099-79-1 5-(3-methoxybenzyl)pyrimidine-2,4,6(1H,3H,5H)-trione 

Relevant articles and documents

Knoevenagel condensation in aqueous media promoted by 2,2′-bipyridinium dihydrogen phosphate as a green efficient catalyst

A 2,2′-Bipyridine-based ionic compound named 2,2′-bipyridinium dihydrogen phosphate was synthesized by addition of phosphoric acid to a solution of 2,2′-Bipyridine in dichloromethane. After the characterization using FT-IR, mass, 1H, 13C and 31P NMR techniques, it was used as a Bronsted dicationic acidic catalyst for the promotion of the synthesis of 2-arylidene malononitrile and 5-arylidene barbituric acid derivatives via Knoevenagel condensation reaction in water. Some of the advantages of this method are the utilization of an easy preparable, cost-effective and eco-friendly organic salt as a catalyst within high rates and yields of the reactions, simple and quick work-up and acceptable reusability of the catalyst.

Preparation and application of triphenyl(propyl-3-hydrogen sulfate)phosphonium bromide as new efficient ionic liquid catalyst for synthesis of 5-arylidene barbituric acids and pyrano[2,3-d]pyrimidine derivatives

We report synthesis of triphenyl(propyl-3-hydrogen sulfate)phosphonium bromide ([TPPHSP]Br) as a reusable green Br?nsted-acidic ionic liquid catalyst and its application for synthesis of 5-arylidene barbituric acids and pyrano[2,3-d]pyrimidine derivatives by condensation reaction between aromatic aldehydes and barbituric acid or aromatic aldehydes, malononitrile, and barbituric acid in EtOH–H2O in reflux condition with good to excellent yield. The [TPPHSP]Br IL catalyst was characterized by Fourier-transform infrared (FT-IR) spectroscopy, 1H and 13C nuclear magnetic resonance (NMR), and thermogravimetric (TG) analysis and showed good catalytic activity and reusability.

2-Phenyl-2,3-dihydrobenzo[ d ]thiazole: A Mild, Efficient, and Highly Active in situ Generated Chemoselective Reducing Agent for the One-Pot Synthesis of 5-Monoalkylbarbiturates in Water

A metal- and catalyst-free reductive alkylation protocol for the one-pot synthesis of 5-monoalkylbarbiturates from barbituric acids and aldehydes using the in situ generated chemoselective reducing agent 2-phenyl-2,3-dihydrobenzo[ d ]thiazole from 2-aminothiophenol and benzaldehyde is described. The notable advantages of the protocol are operational simplicity, mild reaction conditions, high yield, short reaction time, and simple workup and purification process which make it highly attractive.