56514-76-2

Usage

Structure

A derivative of 1-butanone containing an amino group and a methyl group attached to the phenyl ring

Usage

Synthesis of pharmaceuticals and agrochemicals, production of organic compounds, research and development as a building block in the creation of various chemical products

Potential applications

Medicinal chemistry, drug discovery

Known for

Unique chemical structure and properties

Upstream product

• 582-62-7 3-methyl-1-phenylbutan-1-one 
• 78-77-3 Isobutyl bromide 
• 134-20-3 2-carbomethoxyaniline 
• 1263313-63-8 4-chloro-N-[2-(3-methyl-butyryl)-phenyl]-benzene-sulfonamide 
• 83636-63-9 anthranilic acid nitrile 
• 926-62-5 isobutylmagnesium bromide 

Downstream Products

• 942231-85-8 C₁₅H₂₃N₃O₂ 
• 528882-35-1 3-(2-(1-(3,3-dimethyl-2-oxo-butyl)-5-isobutyl-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-benzoic acid 
• 942231-92-7 3-(2-(1-(3,3-dimethyl-2-oxo-butyl)-5-isobutyl-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-benzoic acid methyl ester 
• 851758-04-8 5-fluoro-1,3-dimethyl-1H-pyrazol-4-carboxylic acid [2-(3-methyl-butyryl)-phenyl]-amide 
• 104177-71-1 o-isopentylaniline 

Relevant academic research and scientific papers

One-Pot Synthesis of 4-Quinolone via Iron-Catalyzed Oxidative Coupling of Alcohol and Methyl Arene

Herein, we describe the iron(III)-catalyzed oxidative coupling of alcohol/methyl arene with 2-amino phenyl ketone to synthesize 4-quinolone. Alcohols and methyl arenes are oxidized to the aldehyde in the presence of an iron catalyst and di-tert-butyl peroxide, followed by a tandem process, condensation with amine/Mannich-type cyclization/oxidation, to complete the 4-quinolone ring. This method tolerates various kinds of functional groups and provides a direct approach to the synthesis of 4-quinolones from less functionalized substrates.

Palladium-catalyzed intermolecular directed C-H amidation of aromatic ketones

Pd-catalyzed directed ortho C-H amidation of aromatic ketones with both sulfonamides and amides has been accomplished. The use of an electron-deficient Pd complex, Pd(OTf)2, is crucial for the success of this transformation. Some key intermediates of the reaction, that is, the cyclopalladation complexes of ketones, have been characterized by X-ray crystallography. Experimental analysis of these palladacycles and also the experimental results with N-methyl sulfonamides indicate that the new reaction does not seem to proceed through a nitrene intermediate. The utility of the newly developed reaction was demonstrated for the synthesis of useful organic intermediates such as 2- and 3-alkyl indoles and 2-aminophenyl ketones.

New carboxylic acid amides of the pyrrole series: Synthetic routes and biological aspects

Complex II inhibitors play an important role in agrochemical fungicide research and have been known for more than 40 years. With the introduction of ortho-substituted heterocyclic amides, a breakthrough in activity level and spectrum within this class was achieved. In the meantime all major agrochemical companies have entered this field. In this paper, a special complex II subclass, the pyrrole carboxamides, will be introduced in more detail and the synthesis of selected compounds as well as a short biological SAR analysis of the pyrrole subclass will be discussed.

ISOPENTYL CARBOXANILIDES FOR COMBATING UNDESIRED MICRO-ORGANISMS

The invention relates to novel isopentyl carboxanilides of formula (I), wherein L, R1, R3 and A have the meaning cited in the description, to several methods for the production of said substances and to the use thereof in order to combat undesired micro-organisms, in addition to intermediate products and to the production thereof.

1, 3, 4-BENZOTRIAZEPIN-2-ONE SALTS AND THEIR USE AS CCK RECEPTOR LIGANDS

This invention relates to pharmaceutically acceptable salts of compounds of formula (I) wherein: W is N or N+-O-; R2 is an optionally substituted C1 to C18 hydrocarbyl group wherein up to three C atoms may optionally be replaced by N, O and/or S atoms. R3 is -(CR11R12)m-X-(CR13R14)p-R9; m is 0, 1, 2, 3 or 4; p is 0, 1 or 2; X is a bond, -CR15=CR16-, -C≡C-, C(O)NH, NHC(O), C(O)NMe, NMeC(O), C(O)O, NHC(O)NH, NHC(O)O, OC(O)NH, NH, O, CO, SO2, SO2NH, C(O)NHNH, R9 is H ; C1 to C6 alkyl ; or phenyl, naphthyl, pyridyl, benzimidazolyl, indazolyl, quinolinyl, isoquinolinyl, tetrahydroisoquinolinyl, indolinyl, isoindolinyl, indolyl, isoindolyl or 2-pyridonyl substituted with -L-Q. R4 is an optionally substituted C1 to C18 hydrocarbyl group wherein up to three C atoms may optionally be replaced by N, O and/or S atoms ; and Such salts are useful, for example, for the treatment of gastrin related disorders.