565171-47-3

Basic information

• Product Name: Benzamide, 2-amino-N-[2-(4-methoxyphenyl)ethyl]-
• CAS NO: 565171-47-3
• Molecular Formula: C16H18N2O2
• Molecular Weight: 270.331
• Mol File: 565171-47-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzamide, 2-amino-N-[2-(4-methoxyphenyl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 2-amino-N-[2-(4-methoxyphenyl)ethyl]-(565171-47-3)
• EPA Substance Registry System: Benzamide, 2-amino-N-[2-(4-methoxyphenyl)ethyl]-(565171-47-3)

Safety Data

• Hazardous Substances Data: 565171-47-3(Hazardous Substances Data)

Upstream product

• 118-48-9 isatoic anhydride 
• 55-81-2 4-Methoxyphenethylamine 

Downstream Products

• 1385789-99-0 1-acetyl-3'(4-methoxyphenylethyl)-1'H-spiro[indoline-3,2'-quinazoline]-2,4'(3'H)-dione 
• 1627186-14-4 4-(4-methoxyphenethyl)-2,3,3a,4-tetrahydro-3a-methylpyrrolo[1,2-a]quinazoline-1,5-dione 
• 1426431-50-6 6-(4-methoxyphenethyl)-6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione 
• 1429192-17-5 C₂₂H₂₂N₂O₂S 
• 1221177-07-6 C₃₈H₄₀N₄O₄ 
• 1221176-67-5 C₁₉H₂₂N₂O₂ 
• 75652-63-0 1-methyl-3-<2'-(4-methoxyphenyl)ethyl>-1H,3H-quinazoline-2,4-dione 
• 847238-29-3 3-(4-methoxyphenethyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline 

Relevant articles and documents

Novel quinazolin–sulfonamid derivatives: synthesis, characterization, biological evaluation, and molecular docking studies

In the design of novel drugs, the formation of hybrid molecules via the combination of several pharmacophores can give rise to compounds with interesting biochemical profiles. A series of novel quinazolin–sulfonamid derivatives (9a–m) were synthesized, characterized and evaluated for their in vitro antidiabetic, anticholinergics, and antiepileptic activity. These synthesized novel quinazolin–sulfonamid derivatives (9a–m) were found to be effective inhibitor molecules for the α-glycosidase, human carbonic anhydrase I and II (hCA I and hCA II), butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) enzyme, with Ki values in the range of 100.62 ± 13.68–327.94 ± 58.21 nM for α-glycosidase, 1.03 ± 0.11–14.87 ± 2.63 nM for hCA I, 1.83 ± 0.24–15.86 ± 2.57 nM for hCA II, 30.12 ± 3.81–102.16 ± 13.87 nM for BChE, and 26.16 ± 3.63–88.52 ± 20.11 nM for AChE, respectively. In the last step, molecular docking calculations were made to compare biological activities of molecules against enzymes which are achethylcholinesterase, butyrylcholinesterase and α-glycosidase. Communicated by Ramaswamy H. Sarma.

Syntheses of quinazoline-2,4-dione alkaloids and analogues from Mexican Zanthoxylum species

Quinazolinone and quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties. In this paper we report the synthesis of ten quinazolinediones. The previous isolation of two of these compounds, namely 1-methyl-3-(2′-phenylethyl)-1H,3H-quinazoline-2,4-dione and 1-methyl-3-[2′-(4′-methoxyphenyl)ethyl]-1H,3H-quinazoline-2,4- dione, from the seed husks of Mexican Zanthoxylum species has been reported.