56518-46-8

Upstream product

• 124-38-9 carbon dioxide 
• 1272528-60-5 2-chloro-5-iodo-1,3-dimethoxybenzene 
• 99-10-5 3,5-Dihydroxybenzoic acid 
• 74-88-4 methyl iodide 
• 27971-69-3 2‐chloro‐1,3‐dimethoxy‐5‐methyl benzene 

Downstream Products

• 56518-48-0 4‐chloro‐3,5‐dimethoxybenzaldehyde 

Relevant academic research and scientific papers

Btk INHIBITORS WITH IMPROVED DUAL SELECTIVITY

Disclosed herein is a tri-substituted phenyl Btk inhibitors with improved dual selectivity, a method and a composition for inhibiting Btk and treating disease associated with undesirable Btk activity (Btk-related diseases).

Compound and application thereof

The invention discloses a compound and application thereof. The compound is the compound shown in the formula (I) or a stereoisomer or a pharmaceutical acceptable salt or solvate or a prodrug of the compound shown in the formula (I). The compound can restrain tumor cell proliferation through the effect RRM2, and restrain tumor stem cell regeneration, thereby being effectively used for preparing medicine for preventing or treating proliferative diseases and particularly anti-cancer medicine.

Benzylpyrimidine derivatives

N-oxides of benzylpyrimidines of the formula STR1 wherein R1, R2 and R3 are as set forth hereinafter, are described. The 2,4-diamino-5-(4-bromo-3,5-dimethoxybenzyl)-pyrimidine is also described. The compounds referred to above are useful as potentiators of the antibacterial activity of sulfonamides.